Document Detail

A rat model of progressive chronic renal failure produced by microembolism.
MedLine Citation:
PMID:  10514419     Owner:  NLM     Status:  MEDLINE    
We report a new model of chronic progressive renal failure in rats, produced by a single injection of microspheres (20 to 30 micrometer in diameter) into the left renal artery after right nephrectomy. Significant proteinuria appeared after 4 weeks, followed by hypoalbuminemia and hypercholesterolemia, in rats that received approximately 5 x 10(5) microspheres (0.8 mg). Renal function partially recovered by 4 weeks after nephrectomy and injection from postoperative dysfunction, but deteriorated again 12 weeks after operation. In the early stage, histologic examination showed tubules with cuff-like thickening of basement membranes scattered among apparently intact tubules. Many epithelial cells in the atrophic tubuli were immunoreactive for proliferating cell nuclear antigen (PCNA). Dilated tubules became apparent several weeks after development of tubular atrophy, most likely representing distal tubules. Dilated tubuli were mostly negative for the proliferation marker. These results showed similarity to findings in human chronic renal failure and strongly suggested that tubular atrophy and dilation in chronic tubulointerstitial lesions differ in pathogenesis. This new model of renal failure induced by microembolism should be useful for studying the interaction between normal and diseased tissue elements in histologically heterogenous lesions as well as the pathogenesis of interstitial fibrosis in disturbance of microcirculation.
M Kimura; T Suzuki; A Hishida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of pathology     Volume:  155     ISSN:  0002-9440     ISO Abbreviation:  Am. J. Pathol.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-04     Completed Date:  1999-11-04     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0370502     Medline TA:  Am J Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1371-80     Citation Subset:  AIM; IM    
University of Shizuoka School of Nursing, Shizuoka Hamamatsu University School of Medicine, Hamamatsu, Japan.
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MeSH Terms
Albuminuria / chemically induced
Blood Pressure
Cholesterol / blood
Creatinine / blood
Disease Models, Animal*
Embolism / chemically induced,  complications*,  pathology
Fibrosis / pathology
Kidney Cortex / pathology
Kidney Failure, Chronic / blood,  etiology*,  pathology*,  urine
Kidney Glomerulus / pathology
Kidney Tubules / pathology
Rats, Wistar
Renal Circulation
Serum Albumin / metabolism
Time Factors
Reg. No./Substance:
0/Serum Albumin; 57-88-5/Cholesterol; 60-27-5/Creatinine

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