Document Detail

A rat model of preeclampsia.
MedLine Citation:
PMID:  16303637     Owner:  NLM     Status:  MEDLINE    
Preeclampsia/eclampsia is a disorder of human pregnancy that continues to exact significant maternal morbidity and mortality and fetal wastage. Therapy of these disorders has not changed in over 50 years and there are no proven preventive measures. We describe a model of the development of a syndrome in the pregnant rat that resembles preeclampsia, which results from the imposition of excessive volume expansion early in gestation. We administered desoxycorticosterone acetate (DOCA) to pregnant animals whose drinking water had been replaced with saline. We compared the results obtained in these animals with those resulting from the study of control, virgin animals, virgin animals receiving DOCA and saline, and normal pregnant (NP) animals. The virgin animals given DOCA and saline did not become hypertensive. The experimental paradigm in the DOCA plus saline pregnant (PDS) animals provides many of the phenotypic characteristics of the human disorder including the development of hypertension, proteinuria, and intrauterine growth restriction. In addition, the mean blood nitrite/nitrate concentration was reduced in the PDS rats compared with their NP counterparts. We propose that this model may prove to be useful in the study of the human condition.
Monica Ianosi-Irimie; Hop V Vu; Joy M Whitbred; Candice A Pridjian; J D Nadig; Marian Y Williams; Dené C Wrenn; Gabriella Pridjian; Jules B Puschett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  27     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-23     Completed Date:  2006-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  605-17     Citation Subset:  IM    
Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
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MeSH Terms
Blood Volume / drug effects
Desoxycorticosterone / adverse effects
Disease Models, Animal*
Fetal Growth Retardation / chemically induced,  physiopathology
Hypertension / chemically induced,  physiopathology
Kidney / pathology
Pre-Eclampsia / chemically induced,  physiopathology*
Proteinuria / chemically induced,  physiopathology
Rats, Sprague-Dawley
Sodium Chloride / administration & dosage,  adverse effects
Reg. No./Substance:
64-85-7/Desoxycorticosterone; 7647-14-5/Sodium Chloride

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