Document Detail

The rat as an animal model for endometriosis to examine recurrence of ectopic endometrial tissue after regression.
MedLine Citation:
PMID:  2332064     Owner:  NLM     Status:  MEDLINE    
The effects of pregnancy and ovariectomy on the growth of endometrial implants were examined in rats with experimentally induced endometriosis. Ectopic implants regressed completely after ovariectomy and we were unable to detect any viable endometrial cells in histological examination of the implant sites. Administration of 17 beta-estradiol cypionate to ovariectomized rats with regressed endometrial implants led to recurrence of the regressed implants. Animals with experimentally induced endometriosis were fertile and the number of embryos on day 10 of pregnancy was not different from the control group. Ectopic implants which regressed during pregnancy recurred 1 month after parturition. It is concluded that endometrial cells may survive at the implanted site even after apparent complete morphological regression, which has the potential to grow into an implant.
K Rajkumar; P W Schott; C W Simpson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  53     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-06-06     Completed Date:  1990-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  921-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Saskatchewan, Saskatoon, Canada.
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MeSH Terms
Disease Models, Animal
Endometriosis / physiopathology*
Endometrium / transplantation
Estrogens / pharmacology
Neoplasm Recurrence, Local*
Postpartum Period
Pregnancy Complications
Rats, Inbred Strains
Reg. No./Substance:

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