Document Detail

A rare occurrence of isolated neutropenia with valproic acid: a case report.
MedLine Citation:
PMID:  22187773     Owner:  NLM     Status:  In-Process    
Valproic acid, a conventional antiepileptic drug, is also used in the treatment of bipolar disorder, to provide rapid stabilization of the patient. Although thrombocytopenia is a potential threat, occurrence of suppression of the other cell lines in the bone marrow is also found rarely. Here in this study we report a case of a 28 year old female treated with valproic acid and risperidone for bipolar disorder, who developed isolated neutropenia within 6 months of commencement of therapy that got reversed soon after termination of valproic acid therapy. This finding lays further emphasis on regular monitoring of all cell lines in blood for better management and to prevent any serious bone marrow toxicity in the patients.
Susmita Chakraborty; Jayanta Chakraborty; Srikrishna Mandal; Malay Kumar Ghosal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Indian Medical Association     Volume:  109     ISSN:  0019-5847     ISO Abbreviation:  J Indian Med Assoc     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-12-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505608     Medline TA:  J Indian Med Assoc     Country:  India    
Other Details:
Languages:  eng     Pagination:  345-6     Citation Subset:  IM    
IPGME&R, Kolkata 700020.
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