Document Detail

A rare chimeric TLS/FUS-CHOP transcript in a patient with multiple liposarcomas: a case report.
MedLine Citation:
PMID:  10347549     Owner:  NLM     Status:  MEDLINE    
Myxoid liposarcomas harbor a unique and specific t(12;16)(q13,p11) chromosomal translocation. The breakpoint has recently been identified, and involvement of the TLS/FUS gene on chromosome 16 and the CHOP gene on chromosome 12 was demonstrated. We report a case of a 45-year-old woman who developed multiple malignant lipomatous tumors of unknown origin and myxoid/round cell histology at different locations. To examine the diagnostic potential of this translocation and to develop a hypothesis on the origin of the tumors, we used cytogenetic and molecular cytogenetic methods (reverse transcription polymerase chain reaction, RT-PCR). We identified a chimeric RNA transcript in the second recurrence in the thigh/groin, as well as in another tumor in the mediastinum, which has an additional sequence of 33 bp, known as fusion transcript type III. Cytogenetic analysis of another tumor in retroperitoneal space revealed a rare type of unbalanced translocation der(16)t(12;16). We hypothesize that these tumors are metastases rather than multicentric tumors. The detection of the chimeric message in the present case is not only useful for differential diagnosis, but also for analyzing the origin of multiple neoplasms.
R Schneider-Stock; J Rys; H Walter; J Limon; M Iliszko; A Niezabitowski; A Roessner
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  111     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-06-15     Completed Date:  1999-06-15     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  130-3     Citation Subset:  IM    
Department of Pathology, Otto-von-Guericke University, Magdeburg, Germany.
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MeSH Terms
CCAAT-Enhancer-Binding Proteins*
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 16
DNA-Binding Proteins / genetics*
Heterogeneous-Nuclear Ribonucleoproteins
Liposarcoma / genetics*,  radiotherapy,  secondary
Liposarcoma, Myxoid / genetics,  radiotherapy,  secondary
Liver Neoplasms / genetics,  secondary
Neoplasm Proteins / genetics*
Neoplasm Recurrence, Local / genetics,  radiotherapy
Neoplasms, Second Primary / genetics*,  radiotherapy
RNA-Binding Protein FUS
Retroperitoneal Neoplasms / genetics,  secondary
Reverse Transcriptase Polymerase Chain Reaction
Ribonucleoproteins / genetics*
Transcription Factor CHOP
Transcription Factors / genetics*
Transcription, Genetic
Translocation, Genetic
Reg. No./Substance:
0/CCAAT-Enhancer-Binding Proteins; 0/DDIT3 protein, human; 0/DNA-Binding Proteins; 0/Heterogeneous-Nuclear Ribonucleoproteins; 0/Neoplasm Proteins; 0/RNA-Binding Protein FUS; 0/Ribonucleoproteins; 0/Transcription Factors; 147336-12-7/Transcription Factor CHOP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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