Document Detail

A rare case of ulcerative colitis complicating Wilson's disease: possible association between the two diseases.
MedLine Citation:
PMID:  12080225     Owner:  NLM     Status:  MEDLINE    
A case of ulcerative colitis complicated by Wilson's disease is described. In this case, ulcerative colitis occurred 12 years after the diagnosis of Wilson's disease, and the colitis was intractable to prednisolone and salazosulfapyridine. Because copper is one of the trace elements necessary for antioxidant defenses during inflammatory process, altered copper metabolism may have contributed to the intractability of the ulcerative colitis in this case.
Takahiro Torisu; Motohiro Esaki; Takayuki Matsumoto; Shotaro Nakamura; Koichi Azuma; Mitsuo Okada; Hiroshi Tsuji; Takashi Yao; Mitsuo Iida
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  35     ISSN:  0192-0790     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-06-24     Completed Date:  2002-08-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-5     Citation Subset:  IM    
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Colitis, Ulcerative / complications*,  drug therapy,  metabolism,  pathology
Copper / metabolism
Hepatolenticular Degeneration / complications*
Liver / pathology
Prednisolone / therapeutic use
Sulfasalazine / therapeutic use
Treatment Failure
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 50-24-8/Prednisolone; 599-79-1/Sulfasalazine; 7440-50-8/Copper

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