Document Detail

A rare case of non-Hodgkins B-cell lymphoma in a psoriatic patient: a case report and literature review.
MedLine Citation:
PMID:  20941955     Owner:  NLM     Status:  MEDLINE    
Cyclosporine has been shown to increase the risk of lymphoma when used in organ transplant patients; however, studies have failed to demonstrate an increased risk of lymphoma when used at lower dermatologic doses for psoriasis. The authors present a case of solid B-cell lymphoma occurring in a psoriasis patient with a history of intermittent exposure to high-dose methotrexate, followed by low-dose cyclosporine for two years and subsequently transitioned to treatment with adalimumab. Methotrexate, cyclosporine and adalimumab are each effective treatments for psoriasis. However, when faced with an interplay of several factors, closer surveillance for malignancy is warranted than that which is currently considered for monotherapy.
Shilpa Gattu; Emily M Becker; John Y M Koo
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of drugs in dermatology : JDD     Volume:  9     ISSN:  1545-9616     ISO Abbreviation:  J Drugs Dermatol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-14     Completed Date:  2010-11-04     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  101160020     Medline TA:  J Drugs Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1277-81     Citation Subset:  IM    
Harbor UCLA Medical Center, Torrance, CA, USA.
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MeSH Terms
Antibodies, Monoclonal / adverse effects
Antibodies, Monoclonal, Humanized
Cyclosporine / adverse effects*
Immunosuppressive Agents / adverse effects*
Lymphoma, B-Cell / chemically induced*
Methotrexate / adverse effects
Middle Aged
Psoriasis / drug therapy*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Immunosuppressive Agents; 59-05-2/Methotrexate; 59865-13-3/Cyclosporine; FYS6T7F842/adalimumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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