Document Detail

A rare case of intravascular lymphoma diagnosed on bone marrow trephine.
MedLine Citation:
PMID:  14738155     Owner:  NLM     Status:  MEDLINE    
Intravascular lymphoma (IVL) is an extremely rare form of extra-nodal non-Hodgkins lymphoma characterised by the proliferation of neoplastic lymphocytes within the lumina of small arteries, veins and capillaries. The great majority of reported cases appear to be of B cell lineage. There is a wide variation in clinical presentation, and multiple organs are usually affected. We report a case of a 67-year-old man who presented with constitutional symptoms and neurological deficit and was diagnosed following bone-marrow trephine. His disease responded to polychemotherapy treatment but he died 15 months after diagnosis. This case in unusual in that it is generally felt that bone marrow is relatively spared until late in the disease and is often not clearly demonstrable histologically. In addition, this case supports the limited data that responses can be obtained following polychemotherapy treatment, although the prognosis remains generally poor.
N R Maisey; J S Waters; D Collins; J Schofield; M E Hill
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  44     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2004-01-23     Completed Date:  2004-03-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  1997-2000     Citation Subset:  IM    
Department of Medicine, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK.
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MeSH Terms
Biopsy / methods
Bone Marrow / pathology*
Fatal Outcome
Lymphoma / diagnosis*
Vascular Neoplasms / diagnosis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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