Document Detail

A rare case of early onset nephrotic syndrome in pregnancy.
MedLine Citation:
PMID:  16903255     Owner:  NLM     Status:  MEDLINE    
Nephrotic syndrome occurs very rarely, about 0.012-0.025% of all pregnancies. Here, we report a rare case of early onset nephrotic syndrome developing de novo in the 17th week of pregnancy. A renal biopsy was done and the specimens revealed typical features of focal segmental glomerulosclerosis. The patient had a progressive clinical course of disease despite steroid treatment. Suffering from severe intrauterine growth restriction, the fetus died in utero. After delivery, steroid treatment was continued. The patient had normal renal function with a decrease in proteinuria in the second and fifth month postpartum. This report points out the poor fetal prognosis associated with an early onset nephrotic syndrome. Pregnant patients with early onset nephrotic syndrome should be carefully evaluated for the presence of chronic renal disease, and primary renal pathology should be included in the differential diagnosis of massive proteinuria in early pregnancy.
A Basgul; Z N Kavak; D Sezen; A Basgul; H Gokaslan; F Cakalagaoglu
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  33     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2006  
Date Detail:
Created Date:  2006-08-14     Completed Date:  2006-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  127-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Marmara University School of Medicine, Istanbul Turkey.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Antihypertensive Agents / therapeutic use
Diet, Sodium-Restricted
Fetal Death
Glucocorticoids / therapeutic use
Hypertension, Pregnancy-Induced / diagnosis,  therapy
Kidney / pathology
Methyldopa / therapeutic use
Nephrotic Syndrome / diagnosis*,  therapy
Prednisolone / therapeutic use
Pregnancy Complications / diagnosis*,  therapy
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Glucocorticoids; 50-24-8/Prednisolone; 555-30-6/Methyldopa

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