| A rapidly resorbable hemostatic biomaterial based on dihydroxyacetone. | |
| | |
MedLine Citation:
|
PMID: 19653301 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have developed a rapid acting, rapidly resorbable, non-toxic, topical hemostatic agent comprised of a PEGylated, polymerized sequence of dihydroxyacetone (MPEG-pDHA) that is highly effective in vivo. Twenty-eight Sprague-Dawley rats underwent left lateral hepatectomy. To the cut edge of the liver, rats received MPEG-pDHA (50 mg), normal saline (0.5 mL), or Instat (50 mg), a commercially available hemostatic compound. Bleeding time and total blood loss were quantified. Coagulation studies and scanning electron microscopy were performed on phlebotomized blood combined with MPEG-pDHA. Rats treated with MPEG-pDHA had significantly decreased bleeding time (97 s) and total blood loss (1.35 g) compared to normal saline (464 s and 3.83 g, p < 0.05 for each), and a significantly shorter bleeding time compared to Instat (165 s, p < 0.05). Histology confirmed that all MPEG-pDHA was metabolized within 3 weeks. The addition of MPEG-pDHA to whole blood did not significantly affect prothrombin time (12.0 s vs. 13.2 s, p = 0.130), partial thromboplastin time (27.0 s vs. 21.8 s, p = 0.118), or thrombin clotting time. MPEG-pDHA is an effective and rapidly resorbable hemostatic agent that may find broad hemostatic application in a wide range of surgical procedures. |
| | |
Authors:
|
Peter W Henderson; Daniel J M Kadouch; Sunil P Singh; Peter N Zawaneh; Jennifer Weiser; Sara Yazdi; Andrew Weinstein; Ursula Krotscheck; Bennett Wechsler; David Putnam; Jason A Spector |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of biomedical materials research. Part A Volume: 93 ISSN: 1552-4965 ISO Abbreviation: J Biomed Mater Res A Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-03-25 Completed Date: 2010-06-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101234237 Medline TA: J Biomed Mater Res A Country: United States |
Other Details:
|
Languages: eng Pagination: 776-82 Citation Subset: IM |
Copyright Information:
|
Copyright 2009 Wiley Periodicals, Inc. |
Affiliation:
|
Division of Plastic and Reconstructive Surgery, Laboratory for Bioregenerative Medicine and Surgery, Weill Cornell Medical College, New York, New York, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biocompatible Materials* / chemistry, metabolism Blood Coagulation Tests Dihydroxyacetone* / chemistry, metabolism Hemostatics* / chemistry, metabolism Hepatectomy Liver / injuries Male Materials Testing Molecular Structure Polyethylene Glycols / chemistry, metabolism Random Allocation Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
|
0/Biocompatible Materials; 0/Hemostatics; 0/Polyethylene Glycols; 96-26-4/Dihydroxyacetone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Proligands with protease-regulated binding activity identified from cell-displayed prodomain librari...
Next Document: Chondrogenic differentiation of mesenchymal stem cells induced by collagen-based hydrogel: An in viv...