| Is rapid proliferation in B centroblasts linked to somatic mutation in memory B cell clones? | |
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MedLine Citation:
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PMID: 3263319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antigen-reactive B cells accumulate mutations in the variable (v) regions of their immunoglobulin genes during certain phases of T cell-dependent (TD) antibody responses. This is associated with a rise in the affinity of specific antibody. The time when somatic mutations are accumulating seems to coincide with the presence of germinal centres. This has led to the suggestion that a mechanism leading to a high rate of base pair substitution in immunoglobulin v region genes might operate in centroblasts in germinal centres. The rate of accumulation of mutations in v region genes is likely to relate to the number of specific B cells in cycle and their rate of cell division. The present report provides evidence pointing to centroblasts having a remarkably short cell cycle time of some 6 to 7 hours. This rapid rate of proliferation may explain the clonal expansion which occurs in the early phase of TD antibody responses and the efficiency with which high affinity mutants are subsequently selected. |
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Authors:
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J Zhang; I C MacLennan; Y J Liu; P J Lane |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Immunology letters Volume: 18 ISSN: 0165-2478 ISO Abbreviation: Immunol. Lett. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-12-07 Completed Date: 1988-12-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7910006 Medline TA: Immunol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 297-9 Citation Subset: IM |
Affiliation:
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Department of Immunology, The Medical School, Birmingham, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens B-Lymphocytes / immunology* Cell Division Clone Cells / immunology Immunoglobulin Variable Region / genetics Immunologic Memory* Kinetics Mice Mice, Inbred BALB C Mutation T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Immunoglobulin Variable Region |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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