Document Detail

A randomly-controlled study on the cardiac function at the early stage of return to the plains after short-term exposure to high altitude.
MedLine Citation:
PMID:  22363556     Owner:  NLM     Status:  MEDLINE    
High altitude acclimatization and adaptation mechanisms have been well clarified, however, high altitude de-adaptation mechanism remains unclear. In this study, we conducted a controlled study on cardiac functions in 96 healthy young male who rapidly entered the high altitude (3700 m) and returned to the plains (1500 m) after 50 days. Ninety eight healthy male who remained at low altitude were recruited as control group. The mean pulmonary arterial pressure (mPAP), left ventricular ejection fraction (LVEF), left ventricular fraction shortening (LVFS), cardiac function index (Tei index) were tested. Levels of serum creatine kinase isoform MB (CK-MB), lactate dehydrogenase isoenzyme-1 (LDH-1), endothelin-1 (ET-1), nitrogen oxide (NO), serum hypoxia-inducible factor-1α (HIF-1α), 8-iso-prostaglandin F(2α) (8-iso PGF(2α)), superoxide dismutase (SOD) and malonaldehyde (MDA) were measured at an altitude of 3700 m and 1500 m respectively. The results showed that after short-term exposure to high altitude mPAP and Tei index increased significantly, while LVEF and LVFS decreased significantly. These changes were positively correlated with altitude. On the 15(th) day after the subjects returned to low altitude, mPAP, LVEF and LVFS levels returned to the same level as those of the control subjects, but the Tei index in the returned subjects was still significantly higher than that in the control subjects (P<0.01). We also found that changes in Tei index was positively correlated with mPAP, ET-1, HIF-1α and 8-iso PGF(2α) levels, and negatively correlated with the level of NO, LVEF, LVFS, CK-MB and LDH-1. These findings suggest that cardiac function de-adapts when returning to the plains after short-term exposure to high altitude and the function recovery takes a relatively long time.
Qiquan Zhou; Shengyue Yang; Yongjun Luo; Yushu Qi; Ziqiang Yan; Zifu Shi; Yong Fan
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-02-17
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-24     Completed Date:  2012-06-29     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e31097     Citation Subset:  IM    
Department of High Altitude Diseases, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, China.
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MeSH Terms
Acclimatization / physiology*
Blood Pressure / physiology
Creatine Kinase / blood
Cytokines / blood
Diastole / physiology
Dinoprost / analogs & derivatives,  blood
Environmental Exposure*
Free Radicals / blood
Heart Function Tests*
Hypoxia-Inducible Factor 1, alpha Subunit / blood
Malondialdehyde / metabolism
Myocardium / enzymology
Pulmonary Artery / physiology
Systole / physiology
Time Factors
Young Adult
Reg. No./Substance:
0/Cytokines; 0/Free Radicals; 0/Hypoxia-Inducible Factor 1, alpha Subunit; 27415-26-5/8-epi-prostaglandin F2alpha; 542-78-9/Malondialdehyde; 551-11-1/Dinoprost; EC Kinase

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