Document Detail

A randomized unblinded pilot study comparing albumin versus hydroxyethyl starch in spontaneous bacterial peritonitis.
MedLine Citation:
PMID:  16108036     Owner:  NLM     Status:  MEDLINE    
The administration of albumin improves circulatory function, prevents hepatorenal syndrome, and reduces hospital mortality in patients with cirrhosis and spontaneous bacterial peritonitis. This randomized unblinded pilot study compared the effect of albumin (10 patients) and the synthetic plasma expander hydroxyethyl starch 200/0.5 (10 patients) on the systemic hemodynamics of patients with spontaneous bacterial peritonitis. Baseline measurements were performed within 12 hours after diagnosis of infection. Patients then received 2 doses of the volume expander (1.5 g/kg body weight after baseline measurements and 1 g/kg body weight on day 3). Measurements were repeated after infection resolution. Treatment with albumin was associated with a significant increase in arterial pressure and a suppression of plasma renin activity, indicating an improvement in circulatory function. This occurred in the setting of a significant expansion of central blood volume (increase in cardiopulmonary pressures and atrial natriuretic factor) and an increase in systolic volume and systemic vascular resistance. In contrast, no significant changes were observed in these parameters in patients treated with hydroxyethyl starch. Von Willebrand-related antigen plasma levels significantly decreased in patients treated with albumin but not in those treated with hydroxyethyl starch. Serum nitrates and nitrites increased in patients treated with hydroxyethyl starch but not in those treated with albumin. These data suggest an effect of albumin on endothelial function. In conclusion, albumin but not hydroxyethyl starch improves systemic hemodynamics in patients with spontaneous bacterial peritonitis. This effect is due not only to volume expansion but also to an action on the peripheral arterial circulation.
Javier Fernández; Joan Monteagudo; Xavier Bargallo; Wladimiro Jiménez; Jaume Bosch; Vicente Arroyo; Miguel Navasa
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  42     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-29     Completed Date:  2005-09-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  627-34     Citation Subset:  IM    
Liver Unit, IMDM and IDIBAPS, Hospital Clínic, University of Barcelona, Spain.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Bacterial Infections / therapy*
Ceftriaxone / therapeutic use
Hemodynamics / drug effects,  physiology
Hetastarch / therapeutic use*
Kidney Function Tests
Liver Function Tests
Middle Aged
Peritonitis / therapy*
Pilot Projects
Plasma Substitutes / therapeutic use*
Serum Albumin / therapeutic use*
von Willebrand Factor / metabolism
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Plasma Substitutes; 0/Serum Albumin; 0/von Willebrand Factor; 73384-59-5/Ceftriaxone; 9005-27-0/Hetastarch
Comment In:
Hepatology. 2005 Sep;42(3):533-5   [PMID:  16116626 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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