Document Detail

A randomized trial of yogurt for prevention of antibiotic-associated diarrhea.
MedLine Citation:
PMID:  14627358     Owner:  NLM     Status:  MEDLINE    
Antibiotic-associated diarrhea (AAD) is the most common adverse effect of antibiotic therapy. Our aim was to determine the effectiveness of a dietary supplement of yogurt for prevention of AAD. Two hundred two hospitalized patients receiving oral or intravenous antibiotics were randomized to receive or not receive a dietary yogurt supplement, consisting of 227 grams of commercial yogurt, and followed for 8 days. Mean age of the study group was 70 years and 43% were male. Compliance and 8-day follow-up were 85% and 91%, respectively. Patients receiving yogurt reported less frequent diarrhea (12% vs 24%; P = 0.04), and significantly less total diarrhea] days (23 vs 60). The cumulative proportions of patients without diarrhea were significantly different (P = 0.02) between patients receiving and not receiving yogurt. For conclusion, dietary supplementation with yogurt is a simple, effective, and safe treatment that decreases the incidence and duration of AAD.
Ripudaman S Beniwal; Vincent C Arena; Leno Thomas; Sudhir Narla; Thomas F Imperiale; Rauf A Chaudhry; Usman A Ahmad
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  48     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-20     Completed Date:  2003-12-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2077-82     Citation Subset:  AIM; IM    
Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Roudebush VA Medical Center, (11H) 1481 W. 10th Street, Indianapolis, Indiana 46202, USA.
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MeSH Terms
Administration, Oral
Aged, 80 and over
Anti-Bacterial Agents / administration & dosage,  adverse effects*
Diarrhea / chemically induced*,  epidemiology,  prevention & control*
Injections, Intravenous
Middle Aged
Reg. No./Substance:
0/Anti-Bacterial Agents

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