Document Detail


A randomized trial of two levels of iron supplementation and developmental outcome in low birth weight infants.
MedLine Citation:
PMID:  11487753     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate the effect of increased iron intakes on hematologic status and cognition in low birth weight infants. STUDY DESIGN: We randomly assigned 58 infants to receive formula with 13.4 mg iron/L (normal iron) or 20.7 mg iron/L (high iron). At baseline, discharge, and at 3, 6, 9, and 12 months' corrected age, we assessed anthropometry; infections; red blood cell hemoglobin, catalase, glutathione peroxidase, red blood cell fragility (hydrogen peroxide test), and superoxide dismutase values; plasma malondialdehyde, ferritin, iron, transferrin, zinc and copper levels; and diet intake. Griffiths' Development Assessment was done at 3, 6, 9, and 12 months only. RESULTS: No statistical differences (P <.05) were noted for weight, catalase or malondialdehyde levels, red blood cell fragility, or Griffith's Development Assessment. Iron intakes were greater in the high iron group except at 12 months. Hemoglobin (high iron, 123 +/- 9; normal iron, 118 +/- 8) was not different at 3 months (P =.07). Plasma zinc levels (high iron, 70 +/- 14; normal iron, 89 +/- 27) and copper levels (high iron, 115 +/- 26; normal iron, 132 +/- 27; P =.06) at 12 months suggested inhibition of absorption by high iron formula. Glutathione peroxidase levels were higher in the high iron group. The total number of respiratory tract infections was greater in the high iron group (3.3 +/- 0.9) than in the normal iron group (2.5 +/- 0.9). CONCLUSION: In terms of cognitive outcome, there is no advantage associated with elevated iron intake for low birth weight infants.
Authors:
J K Friel; W L Andrews; K Aziz; P G Kwa; G Lepage; M R L'Abbe
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  139     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-06     Completed Date:  2001-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  254-60     Citation Subset:  AIM; IM    
Affiliation:
Department of Biochemistry, Memorial University of Newfoundland, Janeway Child Health Centre, Grace General Hospital, St John's, Newfoundland, Canada.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Child Development / drug effects*
Cognition / drug effects
Dose-Response Relationship, Drug
Glutathione Peroxidase / metabolism
Humans
Infant, Low Birth Weight*
Infant, Newborn
Iron / administration & dosage,  therapeutic use*
Zinc / blood
Chemical
Reg. No./Substance:
7439-89-6/Iron; 7440-66-6/Zinc; EC 1.11.1.9/Glutathione Peroxidase
Comments/Corrections
Comment In:
J Pediatr. 2002 Jul;141(1):146-7; author reply 147   [PMID:  12091870 ]

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