| A randomized trial of less intense postoperative warfarin or aspirin therapy in the prevention of venous thromboembolism after surgery for fractured hip. | |
| | |
MedLine Citation:
|
PMID: 2650646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A randomized trial was carried out with 194 patients to compare the effectiveness of sodium warfarin or aspirin with that of placebo in the prevention of venous thromboembolism after surgery for fractured hip. Prophylaxis was commenced postoperatively and continued for 21 days or until patient discharge, whichever was earlier. All patients underwent surveillance with iodine 125-fibrinogen leg scanning and impedance plethysmography, with subsequent venography. Venous thromboembolism occurred in 13 patients (20.0%) in the warfarin group, 27 patients (40.9%) in the aspirin group, and 29 patients (46.0%) in the placebo group. Proximal vein thrombosis or pulmonary embolism occurred in 6 patients (9.2%) in the warfarin group, 7 patients (10.6%) in the aspirin group, and 19 patients (30.2%) in the placebo group. The results of this study show that sodium warfarin therapy is safe and effective in preventing thromboembolic complications in patients undergoing surgery for fractured hip, and that aspirin therapy is an equally safe and effective method for preventing proximal vein thrombosis or pulmonary embolism. |
| | |
Authors:
|
P J Powers; M Gent; R M Jay; D H Julian; A G Turpie; M Levine; J Hirsh |
Related Documents
:
|
10678606 - Dosing practices of physicians for anticoagulation with warfarin during inpatient rehab... 20370756 - The efficacy of factor viia in emergency department patients with warfarin use and trau... 20150346 - To continue or discontinue aspirin in the perioperative period: a randomized, controlle... 9387206 - European collaboration on low-dose aspirin in polycythemia vera (eclap): a randomized t... 19701626 - Mid-term results with a highly congruous mobile-bearing knee prosthesis. 11344426 - Is a dissection balloon beneficial in totally extraperitoneal endoscopic hernioplasty (... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Archives of internal medicine Volume: 149 ISSN: 0003-9926 ISO Abbreviation: Arch. Intern. Med. Publication Date: 1989 Apr |
Date Detail:
|
Created Date: 1989-05-18 Completed Date: 1989-05-18 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372440 Medline TA: Arch Intern Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 771-4 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pathology, McMaster University, Hamilton, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Aspirin / administration & dosage* Clinical Trials as Topic Female Follow-Up Studies Hemorrhage / epidemiology Hip Fractures / surgery* Humans Male Middle Aged Phlebography Postoperative Care Postoperative Complications / mortality, prevention & control* Pulmonary Embolism / epidemiology, mortality, prevention & control Random Allocation Thrombophlebitis / epidemiology, prevention & control* Warfarin / administration & dosage* |
| Chemical | |
Reg. No./Substance:
|
50-78-2/Aspirin; 81-81-2/Warfarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Villous tumors of the duodenum.
Next Document: Weight loss and the heart. Effects of anorexia nervosa and starvation.