Document Detail

A randomized trial of exercise and quality of life in colorectal cancer survivors.
MedLine Citation:
PMID:  14982314     Owner:  NLM     Status:  MEDLINE    
We conducted a randomized controlled trial to determine the effects of a home-based exercise intervention on change in quality of life (QOL) in recently resected colorectal cancer survivors, most of whom were receiving adjuvant therapy. Participants were randomly assigned in a 2:1 ratio to either an exercise (n = 69) or control (n = 33) group. The exercise group was asked to perform moderate intensity exercise 3-5 times per week for 20-30 min each time. The primary outcome was change in QOL as measured by the Functional Assessment of Cancer Therapy-Colorectal (FACT-C) scale. Adherence in the exercise group was good (75.8%) but contamination in the control group was problematic (51.6%). Intention-to-treat analysis revealed no significant differences between groups for change in the FACT-C (mean difference, -1.3; 95% CI, -7.8 to 5.1; P = 0.679). In an 'on-treatment' ancillary analysis, we compared participants who decreased versus increased their cardiovascular fitness over the course of the intervention. This analysis revealed significant differences in favour of the increased fitness group for the FACT-C (mean difference, 6.5; 95% CI, 0.4-12.6; P = 0.038). These data suggest that increased cardiovascular fitness is associated with improvements in QOL in colorectal cancer survivors but better controlled trials are needed.
K S Courneya; C M Friedenreich; H A Quinney; A L A Fields; L W Jones; A S Fairey
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer care     Volume:  12     ISSN:  0961-5423     ISO Abbreviation:  Eur J Cancer Care (Engl)     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-02-25     Completed Date:  2004-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9301979     Medline TA:  Eur J Cancer Care (Engl)     Country:  England    
Other Details:
Languages:  eng     Pagination:  347-57     Citation Subset:  N    
Faculty of Physical Education, University of Alberta, Edmonton, Alberta, Canada.
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MeSH Terms
Colorectal Neoplasms / psychology,  rehabilitation*
Exercise Therapy*
Home Care Services
Middle Aged
Patient Compliance
Quality of Life

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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