Document Detail

A randomized trial of exercise and dietary counseling after liver transplantation.
MedLine Citation:
PMID:  16889545     Owner:  NLM     Status:  MEDLINE    
We report results of a randomized clinical trial of a combined intervention of exercise and dietary counseling (ExD) after orthotopic liver transplantation (OLT). Of the 151 patients randomized into ExD or usual care (UC), 119 completed testing 2, 6 and 12 months post-OLT. Testing included assessment of exercise capacity (VO(2peak)), quadricep muscle strength, body composition (DXA), nutritional intake (Block 95) and health-related quality of life (SF-36). The intervention consisted of individualized counseling and follow-up to home-based exercise and dietary modification. Repeated measure ANOVA was performed to determine differences over time between ExD and UC with a secondary analysis to determine differences over time between adherers (Adh), nonadherers (Nadh) to the intervention and UC. The ExD group showed greater increases in VO(2peak) (p = 0.036), and self-reported general health (p = 0.038) compared to UC. Both groups demonstrated increases in muscle strength, body weight, body fat and other SF-36 scale scores. Adherence to the intervention was 37% with positive trends in VO(2peak) and body composition observed in Adh compared to Nadh and UC. These data suggest improvements in exercise capacity and body composition are achieved with nutrition and exercise behavior modifications initiated early after OLT and with regular follow-up.
J B Krasnoff; A Q Vintro; N L Ascher; N M Bass; S M Paul; M J Dodd; P L Painter
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons     Volume:  6     ISSN:  1600-6135     ISO Abbreviation:  Am. J. Transplant.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-07     Completed Date:  2006-11-28     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  100968638     Medline TA:  Am J Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1896-905     Citation Subset:  IM    
Department of Physiological Nursing, University of California, San Francisco, USA.
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MeSH Terms
Adipose Tissue / pathology
Body Height
Body Weight
Liver Transplantation*
Middle Aged
Muscles / physiology
Quality of Life
Time Factors
Comment In:
Nat Clin Pract Gastroenterol Hepatol. 2007 Feb;4(2):70-1   [PMID:  17228292 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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