| A randomized trial of coenzyme Q10 in mitochondrial disorders. | |
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MedLine Citation:
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PMID: 20886510 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Case reports and open-label studies suggest that coenzyme Q(10) (CoQ(10)) treatment may have beneficial effects in mitochondrial disease patients; however, controlled trials are warranted to clinically prove its effectiveness. Thirty patients with mitochondrial cytopathy received 1200 mg/day CoQ(10) for 60 days in a randomized, double-blind, cross-over trial. Blood lactate, urinary markers of oxidative stress, body composition, activities of daily living, quality of life, forearm handgrip strength and oxygen desaturation, cycle exercise cardiorespiratory variables, and brain metabolites were measured. CoQ(10) treatment attenuated the rise in lactate after cycle ergometry, increased (∽1.93 ml) VO(2)/kg lean mass after 5 minutes of cycling (P < 0.005), and decreased gray matter choline-containing compounds (P < 0.05). Sixty days of moderate- to high-dose CoQ(10) treatment had minor effects on cycle exercise aerobic capacity and post-exercise lactate but did not affect other clinically relevant variables such as strength or resting lactate. |
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Authors:
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Elisa I Glover; Joan Martin; Amy Maher; Rebecca E Thornhill; Gerald R Moran; Mark A Tarnopolsky |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Muscle & nerve Volume: 42 ISSN: 1097-4598 ISO Abbreviation: Muscle Nerve Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-26 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 739-48 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Activities of Daily Living Adult Anaerobic Threshold / drug effects Antioxidants / metabolism, therapeutic use* Body Composition / physiology Brain Chemistry / drug effects Choline / metabolism Cross-Over Studies Double-Blind Method Exercise Test Female Forearm / physiology Hemodynamics / drug effects Humans Isometric Contraction / physiology Lactic Acid / blood Magnetic Resonance Spectroscopy Male Middle Aged Mitochondrial Diseases / drug therapy* Muscle Fatigue / physiology Oxidative Stress / physiology Oxygen Consumption / physiology Quality of Life Spectroscopy, Near-Infrared Ubiquinone / analogs & derivatives*, blood, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10; 50-21-5/Lactic Acid; 62-49-7/Choline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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