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A randomized trial of aggressive versus conservative phototherapy for hyperbilirubinemia in infants weighing less than 1500 g: Short- and long-term outcomes.
MedLine Citation:
PMID:  19043499     Owner:  NLM     Status:  PubMed-not-MEDLINE    
OBJECTIVE: Treatment regimens for hyperbilirubinemia vary for very low birth weight infants. The present study seeks to determine whether the initiation of conservative phototherapy is as effective as aggressive phototherapy in reducing peak bilirubin levels without increasing adverse effects.
STUDY DESIGN: The present randomized, controlled study included infants with birth weights between 500 g and 1500 g, stratified into two birth weight groups. In one group, aggressive phototherapy was commenced by 12 h of age, while in the other group, conservative phototherapy was commenced if serum bilirubin levels exceeded 150 mumol/L. The primary outcome variables were peak serum bilirubin levels and hours of phototherapy. Secondary outcomes were age at peak bilirubin levels, number of infants with rebound hyperbilirubinemia, and number of adverse short- and long-term outcomes.
RESULTS: Of 174 eligible infants, 95 consented to participate -49 in the conservative arm and 46 in the aggressive arm. Ninety-two infants completed the study. There was no significant difference in peak bilirubin levels except in infants who weighed less than 1000 g -171.2+/-26 mumol/L (conservative) versus 139.2+/-46 mumol/L (aggressive); P<0.02. There was no difference in duration of phototherapy or rebound hyperbilirubinemia. There were no differences in short-term adverse outcomes. Of the 87 infants who survived until hospital discharge, 82 (94%) had some follow-up and 75 (86%) attended follow-up until 18 months corrected age. The incidence of cerebral palsy, abnormal mental developmental index at 18 months corrected age, or combined outcome of cerebral palsy and death did not significantly differ between the two groups.
CONCLUSIONS: In infants weighing less than 1000 g, peak bilirubin levels were significantly higher using conservative phototherapy regimens and there was a tendency for poor neurodevelopmental outcome.
Krista A Jangaard; Michael J Vincer; Alexander C Allen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Paediatrics & child health     Volume:  12     ISSN:  1205-7088     ISO Abbreviation:  Paediatr Child Health     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-12-01     Completed Date:  2011-07-14     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  9815960     Medline TA:  Paediatr Child Health     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  853-8     Citation Subset:  -    
Department of Neonatal Pediatrics, Dalhousie University, Halifax, Nova Scotia.
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