| A randomized study of beef lung and pork mucosal heparin in cardiac surgery. | |
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MedLine Citation:
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PMID:Â 6344819 Â Â Â Owner:Â NLM Â Â Â Status:Â MEDLINE Â Â Â |
Abstract/OtherAbstract:
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Beef lung heparin had substantially greater anticoagulant activity than pork mucosal heparin during a preoperative heparin tolerance test and also during cardiopulmonary bypass (CPB) in 100 randomized patients. Supplemental heparin was needed during CPB in many more of the patients receiving pork mucosal heparin. Heparin rebound was detected in 16 patients; this low incidence may result from a relatively high protamine:heparin ratio. There was notably less postoperative bleeding in those who received beef lung heparin. Platelet counts were not altered by either type of heparin. It is surprising that the preoperative tolerance curve only predicted heparin sensitivity during CPB in one-half of the patients. Blood activated coagulation time levels were increased markedly by hemodilution and further raised by hypothermia. These data demonstrate that beef lung heparin is better than pork mucosal heparin for CPB. |
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Authors:
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W P Fiser; R C Read; F E Wright; T J Vecchio |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    |
Journal Detail:
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Title: The Annals of thoracic surgery    Volume: 35    ISSN: 0003-4975    ISO Abbreviation: Ann. Thorac. Surg.    Publication Date: 1983 Jun |
Date Detail:
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Created Date:Â 1983-07-08 Â Â Â Completed Date:Â 1983-07-08 Â Â Â Revised Date:Â 2007-11-15 Â Â Â |
Medline Journal Info:
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Nlm Unique ID: 15030100R    Medline TA: Ann Thorac Surg    Country: UNITED STATES    |
Other Details:
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Languages: eng    Pagination: 615-20    Citation Subset: AIM; IM    |
Export Citation:
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APA/MLA Format    Download EndNote    Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiopulmonary Bypass / methods* Cattle Clinical Trials as Topic Dose-Response Relationship, Drug Drug Tolerance Heparin / adverse effects, pharmacology* Heparin Antagonists Humans Prospective Studies Protamines / pharmacology Random Allocation Swine |
| Chemical | |
Reg. No./Substance:
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0/Heparin Antagonists; 0/Protamines; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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