Document Detail

A randomized prospective comparison of nifedipine and bed rest versus bed rest alone in the management of preeclampsia remote from term.
MedLine Citation:
PMID:  1415419     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of our study was to test the hypothesis that treatment with nifedipine for mild preeclampsia remote from term reduces the number of days of maternal hospitalization and improves pregnancy outcome. STUDY DESIGN: A total of 200 patients at 26 to 36 weeks' gestation were randomly allocated to treatment with either bed rest alone (n = 100) or bed rest in combination with nifedipine (n = 100). RESULTS: Patients receiving nifedipine had significantly lower systolic (p < 0.0001) and diastolic (p < 0.0001) blood pressures during therapy. Severe hypertension as an indication for delivery was significantly (p < 0.05) more frequent in the bed-rest-alone group. The two study groups had similar average days of maternal hospitalization (12.6 +/- 7.9 vs 12.3 +/- 10.3) and pregnancy prolongation (22.3 +/- 13.5 vs 22.5 +/- 15.7). There were no differences between groups with respect to birth weight, incidences of small-for-gestational-age infants and preterm birth, number of days spent in special care unit, or cord blood gas measurement. CONCLUSION: Nifedipine therapy for preeclampsia reduces maternal blood pressure but does not reduce number of days of maternal hospitalization or improve perinatal outcome.
B M Sibai; J R Barton; S Akl; C Sarinoglu; B M Mercer
Related Documents :
14624279 - Endothelium and hypertensive disorders in pregnancy.
4186729 - Association between foeto-maternal bleeding and hypertension in pregnancy.
9773389 - Two cases of primary pulmonary hypertension diagnosed during pregnancy.
7687229 - Tumor markers in hypertensive disorders of pregnancy.
17495859 - Prenatal programming of nephron number and blood pressure.
9219129 - Felodipine use in pregnancy. report of three cases.
3679859 - Myocardial infarction during pregnancy: a team challenge.
12600729 - Effect of recombinant bovine somatotropin on superovulatory response and recipient preg...
23901179 - Effect of intermittent preventive treatment of malaria on the outcome of pregnancy amon...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  167     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-11-17     Completed Date:  1992-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  879-84     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Tennessee, Memphis.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bed Rest*
Blood Pressure
Nifedipine / therapeutic use*
Pre-Eclampsia / complications,  physiopathology,  therapy*
Pregnancy Outcome
Pregnancy Trimester, First
Pregnancy Trimester, Second
Prospective Studies
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Neonatal periventricular-intraventricular hemorrhage after maternal beta-sympathomimetic tocolysis. ...
Next Document:  Magnesium pyrrolidone carboxylate infusion reduces angiotensin II pressor response in pregnant women...