Document Detail


A randomized placebo-controlled trial of erythromycin for the treatment of Ureaplasma urealyticum to prevent premature delivery. The Vaginal Infections and Prematurity Study Group.
MedLine Citation:
PMID:  2003533     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ureaplasma urealyticum has been associated with low birth weight and histologic chorioamnionitis and it is a frequent isolate from the chorioamnion of patients who are delivered prematurely. In prior clinical trials using antibiotics active against U. urealyticum, antibiotic treatment was associated with reduced prematurity and increased mean birth weight. In this multicenter, randomized, double-blind clinical trial, pregnant women with U. urealyticum were treated with 333 mg of erythromycin base or placebo three times daily, starting between 26 and 30 weeks' gestation and continuing through 35 completed weeks of pregnancy. Women with urinary tract infection or Neisseria gonorrhoeae infection were excluded from the trial, and women with Chlamydia trachomatis or group B streptococci were excluded from these analyses. Erythromycin did not eliminate U. urealyticum from the lower genital tract. There were no significant differences between erythromycin- and placebo-treated women in infant birth weight or gestational age at delivery, in frequency of premature rupture of membranes, or in neonatal outcome.
Authors:
D A Eschenbach; R P Nugent; A V Rao; M F Cotch; R S Gibbs; K A Lipscomb; D H Martin; J G Pastorek; P J Rettig; J C Carey
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  164     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-15     Completed Date:  1991-04-15     Revised Date:  2012-03-07    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  734-42     Citation Subset:  AIM; IM    
Affiliation:
University of Washington, Seattle.
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MeSH Terms
Descriptor/Qualifier:
Adult
Erythromycin / therapeutic use*
Female
Humans
Mycoplasmatales Infections / drug therapy*
Obstetric Labor, Premature / prevention & control*
Pregnancy
Pregnancy Complications, Infectious / drug therapy*
Pregnancy Outcome
Ureaplasma / drug effects*
Grant Support
ID/Acronym/Agency:
HD-3-2832/HD/NICHD NIH HHS; HD-3-2833/HD/NICHD NIH HHS; HD-3-2834/HD/NICHD NIH HHS; Z99 EY999999/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
114-07-8/Erythromycin
Comments/Corrections
Comment In:
Am J Obstet Gynecol. 1992 Feb;166(2):767-8   [PMID:  1536263 ]
Am J Obstet Gynecol. 1992 Jun;166(6 Pt 1):1864-5   [PMID:  1615998 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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