| A randomized, placebo-controlled laboratory study of the effects of D: -cycloserine on craving in cocaine-dependent individuals. | |
| | |
MedLine Citation:
|
PMID: 22234379 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
RATIONALE: D: -Cycloserine (DCS), a partial glutamate N-methyl-D: -aspartate (NMDA) receptor agonist, enhances extinction of conditioned fear responding; preliminary data suggest that it may facilitate extinction of drug cue reactivity. OBJECTIVE: This study investigates DCS effects on cocaine cue craving and drug use in cocaine-dependent subjects. METHODS: Thirty-two subjects were randomly assigned to receive (1) DCS only, (2) DCS before sessions 1 and 3, placebo (PBO) before session 2, or (3) PBO only 15-min before each of 3 1-h cocaine cue exposure sessions conducted 1 day apart. Craving ratings were obtained before, during, and after sessions. Drug use and cue-induced craving were assessed 1 week after the last cue session. RESULTS: Repeated presentation of cocaine cues resulted in decreased craving both within and between sessions. DCS did not facilitate extinction learning and may have enhanced craving. The group that received three doses of DCS had significantly higher craving than the PBO group at the baseline ratings taken before sessions 2 and 3, as well as significantly higher cue-induced craving at follow-up. The group that received two doses of DCS did not differ from the PBO group. There were no group differences in postextinction cocaine use. CONCLUSIONS: The reduction of cocaine cue reactivity in the PBO group suggests that the study procedures were sufficient to produce extinction. Under these conditions, DCS did not facilitate extinction and may have enhanced craving. Further studies of glutamatergic agents and extinction in cocaine dependence should include consideration of procedural variables that could have a major impact on study outcomes. |
| | |
Authors:
|
Kimber L Price; Nathaniel L Baker; Aimee L McRae-Clark; Michael E Saladin; Stacia M Desantis; Elizabeth J Santa Ana; Kathleen T Brady |
Related Documents
:
|
22972059 - Alpha-foetoprotein and/or liver ultrasonography for screening of hepatocellular carcino... 21105839 - 'profox' - the post hrt nightmare. 19525739 - The effect of psychotherapy added to pharmacotherapy on cortisol responses in outpatien... 22411849 - Erythropoietin in friedreich ataxia: no effect on frataxin in a randomized controlled t... 6196059 - Cerebrospinal fluid biochemical examinations: do they reflect clinical or biological di... 3922959 - Use of biologic markers in a general hospital affective disorders program. 6387599 - Higher nervous activity in psychiatric patients. 11188499 - Reliability and validity of the german version of the european addiction severity index... 1336069 - Inpatient and outpatient cocaine abusers: clinical comparisons at intake and one-year f... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-11 |
Journal Detail:
|
Title: Psychopharmacology Volume: - ISSN: 1432-2072 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Psychiatry and Behavioral Sciences, Division of Clinical Neuroscience, Medical University of South Carolina, 67 President Street MSC 861, Charleston, SC, 29425, USA, kimber.l.price@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory...
Next Document: The effects of exercise on cigarette cravings and brain activation in response to smoking-related im...