Document Detail

A randomized, placebo-controlled laboratory study of the effects of D-cycloserine on craving in cocaine-dependent individuals.
MedLine Citation:
PMID:  22234379     Owner:  NLM     Status:  MEDLINE    
RATIONALE: D-Cycloserine (DCS), a partial glutamate N-methyl-D-aspartate (NMDA) receptor agonist, enhances extinction of conditioned fear responding; preliminary data suggest that it may facilitate extinction of drug cue reactivity.
OBJECTIVE: This study investigates DCS effects on cocaine cue craving and drug use in cocaine-dependent subjects.
METHODS: Thirty-two subjects were randomly assigned to receive (1) DCS only, (2) DCS before sessions 1 and 3, placebo (PBO) before session 2, or (3) PBO only 15-min before each of 3 1-h cocaine cue exposure sessions conducted 1 day apart. Craving ratings were obtained before, during, and after sessions. Drug use and cue-induced craving were assessed 1 week after the last cue session.
RESULTS: Repeated presentation of cocaine cues resulted in decreased craving both within and between sessions. DCS did not facilitate extinction learning and may have enhanced craving. The group that received three doses of DCS had significantly higher craving than the PBO group at the baseline ratings taken before sessions 2 and 3, as well as significantly higher cue-induced craving at follow-up. The group that received two doses of DCS did not differ from the PBO group. There were no group differences in postextinction cocaine use.
CONCLUSIONS: The reduction of cocaine cue reactivity in the PBO group suggests that the study procedures were sufficient to produce extinction. Under these conditions, DCS did not facilitate extinction and may have enhanced craving. Further studies of glutamatergic agents and extinction in cocaine dependence should include consideration of procedural variables that could have a major impact on study outcomes.
Kimber L Price; Nathaniel L Baker; Aimee L McRae-Clark; Michael E Saladin; Stacia M Desantis; Elizabeth J Santa Ana; Kathleen T Brady
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-01-11
Journal Detail:
Title:  Psychopharmacology     Volume:  226     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-08     Completed Date:  2013-10-28     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  739-46     Citation Subset:  IM    
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MeSH Terms
Cocaine-Related Disorders / drug therapy*
Cycloserine / pharmacology*
Double-Blind Method
Extinction, Psychological / drug effects*
Fear / drug effects*
Follow-Up Studies
Middle Aged
Treatment Outcome
Grant Support
1R01DA023188-01A1/DA/NIDA NIH HHS; 3R01DA023188-02S1/DA/NIDA NIH HHS; R01 DA023188/DA/NIDA NIH HHS; R01 DA023188-01A1/DA/NIDA NIH HHS; R01 DA023188-02S1/DA/NIDA NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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