Document Detail


A randomized, placebo-controlled clinical trial on the effects of recombinant human relaxin on tooth movement and short-term stability.
MedLine Citation:
PMID:  22284287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Moving teeth rapidly and avoiding posttreatment relapse are fundamental goals of orthodontic treatment. In-vitro and animal studies suggest that the human hormone relaxin might increase the rate of movement and the stability through its effect on the periodontal ligament. The purpose of this study was to compare relaxin and a placebo with regard to tooth movement and stability in human subjects.
METHODS: A single-center, blinded, placebo-controlled, randomized clinical trial was used to examine the effect of relaxin on tooth movement and stability. Forty subjects were randomized 1:1 and received weekly injections of 50 μg of relaxin or a placebo for 8 weeks. Aligners programmed to move a target tooth 2 mm during treatment were dispensed at weeks 0, 2, 4, and 6. Movement was measured weekly on polyvinyl siloxane impressions that were scanned and digitized. The subjects were followed through week 12 to assess relapse.
RESULTS: Tooth movement over the 8-week treatment period did not differ by treatment group (P = 0.995). By using an intent-to-treat analysis, we found that the mean tooth movement for both groups was 0.83 mm (SE, 0.08 for relaxin and 0.09 for the placebo). Relapse from weeks 8 to 12 was the same in both groups (P = 0.986), and the mean was -0.75 (SE, 0.07 for relaxin and 0.08 for theplacebo).
CONCLUSIONS: No differences in tooth movement over 8 weeks of treatment or relapse at 4 weeks posttreatment were detected when comparing subjects who received weekly injections of relaxin with those who received a placebo. In both groups, an average of less than half of the programmed tooth movement was obtained after 8 weeks of treatment. The local doses of relaxin might have been too low to affect tooth movement or short-term relapse.
Authors:
Susan P McGorray; Calogero Dolce; Susan Kramer; Dennis Stewart; Timothy T Wheeler
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics     Volume:  141     ISSN:  1097-6752     ISO Abbreviation:  Am J Orthod Dentofacial Orthop     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-30     Completed Date:  2012-04-03     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  8610224     Medline TA:  Am J Orthod Dentofacial Orthop     Country:  United States    
Other Details:
Languages:  eng     Pagination:  196-203     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2012 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.
Affiliation:
Department of Biostatistics, University of Florida, Gainesville, Fla., USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cohort Studies
Dental Models
Female
Follow-Up Studies
Humans
Incisor / pathology
Injections
Male
Malocclusion / therapy
Orthodontic Appliance Design
Periodontal Ligament / drug effects
Placebos
Recombinant Proteins
Recurrence
Relaxin / therapeutic use*
Single-Blind Method
Stress, Mechanical
Tooth Movement / instrumentation,  methods*
Young Adult
Grant Support
ID/Acronym/Agency:
1UL1RR029890/RR/NCRR NIH HHS; UL1 RR029890/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Placebos; 0/Recombinant Proteins; 9002-69-1/Relaxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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