Document Detail

A randomized multicenter study to determine the efficacy of activity restriction for preterm labor management in patients testing negative for fetal fibronectin.
MedLine Citation:
PMID:  16107874     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the impact of activity restriction (AR) on the incidence of preterm birth in women treated for preterm labor testing negative for fetal fibronectin (fFN). STUDY DESIGN: Women who were diagnosed with preterm labor and tocolyzed with magnesium sulfate were concurrently screened with fFN for the purpose of subsequent management. Included were consenting patients with negative fFN, gestational age 23 0/7-33 6/7 weeks, cervical dilation < or =3 cm, and minimal vaginal bleeding. Patients were randomized to AR or no AR. Primary study outcome was incidence of preterm delivery and interval from randomization to delivery. RESULTS: A total of 73 women with negative fFN were randomized (36 with AR, 37 without AR). The overall preterm birth rate was 40%, with 44.4% of patients with AR and 35.1% of patients without AR delivering preterm, p=0.478. CONCLUSION: Maternal AR did not impact pregnancy outcome. The incidence of preterm birth in symptomatic women testing fFN negative was higher than previously reported.
John P Elliott; Hugh S Miller; Suzanne Coleman; Debbie Rhea; Diana Abril; Karen Hallbauer; Niki B Istwan; Gary J Stanziano
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  25     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-29     Completed Date:  2006-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  626-30     Citation Subset:  IM    
Phoenix Perinatal Associates, Division of Obstetrix Medical Group of Arizona, AZ 85006, USA.
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MeSH Terms
Bed Rest*
Fibronectins / analysis*
Gestational Age
Glycoproteins / analysis*
Infant, Newborn
Magnesium Sulfate / administration & dosage
Obstetric Labor, Premature / prevention & control*
Pregnancy Outcome
Prospective Studies
Tocolytic Agents / administration & dosage
Reg. No./Substance:
0/FFN protein, human; 0/Fibronectins; 0/Glycoproteins; 0/Tocolytic Agents; 7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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