| A randomized, multicenter study comparing the efficacy of recombinant FSH vs recombinant FSH with Ganirelix during superovulation/IUI therapy. | |
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MedLine Citation:
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PMID: 15343256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The purpose of this study was to determine if use of a Gonadotropin releasing hormone (GnRH) antagonist, Ganirelix (Antagon), can improve pregnancy rates during superovulation with recombinant follicle-stimulating hormone (rFSH) followed by intrauterine insemination (IUI). STUDY DESIGN: This was a multicenter, prospective, randomized, open-label, assessor-blind, controlled trial of females (n = 54), ages 18 to 39 undergoing superovulation/IUI with up to 4 cycles of superovulation/IUI without Ganirelix (n = 66), or up to 4 cycles of superovulation/IUI with the addition of Ganirelix (n = 52). RESULTS: No statistically significant difference in clinical pregnancy rates per cycle initiated was found for patients in the treatment or control group (12% vs 7%, P =.29). Other variables assessed, including endometrial thickness, size of follicles, peak serum estradiol levels, mid-lutea progesterone levels, and total vials of rFSH used also showed no statistically significant difference. CONCLUSION: Superovulation/IUI cycles using Ganirelix produce similar pregnancy rates when compared with cycles not using a GnRH antagonist, although there is a trend towards better pregnancy rates in cycles with Ganirelix. |
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Authors:
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R Stan Williams; Jessica B Hillard; Gary De Vane; Tim Yeko; Simon Kipersztok; Alice Rhoton-Vlasak; Chris Sistrom |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 191 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-09-02 Completed Date: 2004-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 648-51; discussion 651-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL 32607, USA. Williams@obgyn.ufl.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Drug Therapy, Combination Female Follicle Stimulating Hormone, Human / therapeutic use* Gonadotropin-Releasing Hormone / analogs & derivatives*, antagonists & inhibitors*, therapeutic use* Humans Infertility, Female / therapy* Insemination, Artificial / methods* Pregnancy Pregnancy Outcome* Pregnancy Rate Superovulation* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Follicle Stimulating Hormone, Human; 123246-29-7/ganirelix; 33515-09-2/Gonadotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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