Document Detail


A randomized, multicenter study comparing the efficacy of recombinant FSH vs recombinant FSH with Ganirelix during superovulation/IUI therapy.
MedLine Citation:
PMID:  15343256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to determine if use of a Gonadotropin releasing hormone (GnRH) antagonist, Ganirelix (Antagon), can improve pregnancy rates during superovulation with recombinant follicle-stimulating hormone (rFSH) followed by intrauterine insemination (IUI). STUDY DESIGN: This was a multicenter, prospective, randomized, open-label, assessor-blind, controlled trial of females (n = 54), ages 18 to 39 undergoing superovulation/IUI with up to 4 cycles of superovulation/IUI without Ganirelix (n = 66), or up to 4 cycles of superovulation/IUI with the addition of Ganirelix (n = 52). RESULTS: No statistically significant difference in clinical pregnancy rates per cycle initiated was found for patients in the treatment or control group (12% vs 7%, P =.29). Other variables assessed, including endometrial thickness, size of follicles, peak serum estradiol levels, mid-lutea progesterone levels, and total vials of rFSH used also showed no statistically significant difference. CONCLUSION: Superovulation/IUI cycles using Ganirelix produce similar pregnancy rates when compared with cycles not using a GnRH antagonist, although there is a trend towards better pregnancy rates in cycles with Ganirelix.
Authors:
R Stan Williams; Jessica B Hillard; Gary De Vane; Tim Yeko; Simon Kipersztok; Alice Rhoton-Vlasak; Chris Sistrom
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  191     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-09-02     Completed Date:  2004-09-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  648-51; discussion 651-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Florida, Gainesville, FL 32607, USA. Williams@obgyn.ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Drug Therapy, Combination
Female
Follicle Stimulating Hormone, Human / therapeutic use*
Gonadotropin-Releasing Hormone / analogs & derivatives*,  antagonists & inhibitors*,  therapeutic use*
Humans
Infertility, Female / therapy*
Insemination, Artificial / methods*
Pregnancy
Pregnancy Outcome*
Pregnancy Rate
Superovulation*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Follicle Stimulating Hormone, Human; 123246-29-7/ganirelix; 33515-09-2/Gonadotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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