| A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. | |
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MedLine Citation:
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PMID: 9915448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Nitric oxide synthase activity is decreased in the urine of patients with interstitial cystitis compared to the urine of controls. In a preliminary trial oral L-arginine, the substrate for nitric oxide synthase, increased urinary nitric oxide synthase activity and improved interstitial cystitis symptoms. This randomized, double-blind, placebo controlled study further investigates the efficacy of L-arginine treatment for interstitial cystitis. MATERIALS AND METHODS: A total of 53 interstitial cystitis patients were assigned to receive daily 1,500 mg. L-arginine or placebo orally for 3 months. Interstitial cystitis symptoms were assessed by interviews at 2 weeks, and 1, 2 and 3 months. RESULTS: The trial was completed by 21 of 27 patients in the L-arginine group and 25 of 26 in the placebo group. Using per protocol analysis 29% (6 of 21 patients) in the L-arginine group and 8% (2 of 25) in the placebo group were clinically improved by the end of the trial (p = 0.07). A Likert scale showed greater global improvement in the L-arginine group (48%, 10 of 21) compared to the placebo group (24%, 6 of 25) at 3 months (p = 0.05) with a decrease in pain intensity (p = 0.04), and tendency toward improvement in urgency (p = 0.06) and frequency of pain (p = 0.09). Using an intention to treat approach to analysis there were no differences between groups. CONCLUSIONS: Oral L-arginine (1,500 mg. daily) may decrease pain and urgency in a subset of interstitial cystitis patients. |
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Authors:
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G E Korting; S D Smith; M A Wheeler; R M Weiss; H E Foster |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of urology Volume: 161 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-02-18 Completed Date: 1999-02-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 558-65 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520-8041, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Arginine / administration & dosage* Cystitis, Interstitial / drug therapy* Double-Blind Method Female Follow-Up Studies Humans Middle Aged Questionnaires |
| Grant Support | |
ID/Acronym/Agency:
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DK02499/DK/NIDDK NIH HHS; DK38311/DK/NIDDK NIH HHS; DK47548/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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74-79-3/Arginine |
| Comments/Corrections | |
Comment In:
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J Urol. 2000 Nov;164(5):1666
[PMID:
11025740
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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