| A randomized double-blind study using CaNa2EDTA, a phospholipase A2 inhibitor, in the management of human acute pancreatitis. | |
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MedLine Citation:
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PMID: 3922048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a randomized double-blind study the effect of CaNa2EDTA, a phospholipase A2 inhibitor, was tested as a treatment for acute pancreatitis. CaNa2EDTA was infused intravenously during the first 2 days after admission to hospital, in addition to normal conservative treatment. CaNa2EDTA decreased the serum phospholipase A2 activity and appeared to promote recovery from the illness. To what extent the inhibition of serum phospholipase activity may prevent the progress of severe haemorrhagic pancreatitis or diminish mortality and morbidity in acute pancreatitis should be investigated in further studies. |
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Authors:
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H T Tykkä; E J Vaittinen; K L Mahlberg; J E Railo; P J Pantzar; S Sarna; T Tallberg |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 20 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1985 Jan |
Date Detail:
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Created Date: 1985-06-03 Completed Date: 1985-06-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 5-12 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Annexins Calcium-Binding Proteins* Clinical Trials as Topic Double-Blind Method Edetic Acid / therapeutic use* Female Glycoproteins / therapeutic use* Humans Male Middle Aged Pancreatitis / drug therapy*, metabolism Phospholipases / antagonists & inhibitors* Phospholipases A / antagonists & inhibitors* Phospholipases A2 Random Allocation |
| Chemical | |
Reg. No./Substance:
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0/Annexins; 0/Calcium-Binding Proteins; 0/Glycoproteins; 0/lipomodulin; 60-00-4/Edetic Acid; EC 3.1.-/Phospholipases; EC 3.1.1.-/Phospholipases A; EC 3.1.1.4/Phospholipases A2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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