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A randomized, double-blind, placebo-controlled, crossover, dose-ranging multicenter study to determine the effect of sublingual nitroglycerin spray on exercise capacity in patients with chronic stable angina.
MedLine Citation:
PMID:  22566749     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Sublingual nitroglycerin increases exercise duration in patients with stable angina. Brief results from this study were published previously in German. Here, we more fully describe the study methodology, patient characteristics, and detailed results.
METHODS: This double-blind, crossover study enrolled 51 patients with stable angina. Patients were randomized to 1 of 5 treatment sequences and were administered placebo or nitroglycerin spray (0.2 mg, 0.4 mg, 0.8 mg, or 1.6 mg). Patients carried out 1 control exercise tolerance test (ETT) and 1 investigational ETT at each visit.
RESULTS: Dose-dependent increases in time to onset of angina, time to onset of moderate angina, and the occurrence of a minimum 1.0-mm ST-segment depression were seen following administration of nitroglycerin spray.
CONCLUSIONS: These results support the use of sublingual nitroglycerin spray in patients with stable angina who are being managed with medical therapy and in patients who have persistent angina post-revascularization.
Udho Thadani; Thomas Wittig
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Publication Detail:
Type:  Journal Article     Date:  2012-04-23
Journal Detail:
Title:  Clinical Medicine Insights. Cardiology     Volume:  6     ISSN:  1179-5468     ISO Abbreviation:  Clin Med Insights Cardiol     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-08     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101525768     Medline TA:  Clin Med Insights Cardiol     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  87-95     Citation Subset:  -    
Department of Medicine, Cardiovascular Section, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, OK.
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