| A randomized, double-blind, placebo-controlled, crossover, dose-ranging multicenter study to determine the effect of sublingual nitroglycerin spray on exercise capacity in patients with chronic stable angina. | |
| | |
MedLine Citation:
|
PMID: 22566749 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Sublingual nitroglycerin increases exercise duration in patients with stable angina. Brief results from this study were published previously in German. Here, we more fully describe the study methodology, patient characteristics, and detailed results. METHODS: This double-blind, crossover study enrolled 51 patients with stable angina. Patients were randomized to 1 of 5 treatment sequences and were administered placebo or nitroglycerin spray (0.2 mg, 0.4 mg, 0.8 mg, or 1.6 mg). Patients carried out 1 control exercise tolerance test (ETT) and 1 investigational ETT at each visit. RESULTS: Dose-dependent increases in time to onset of angina, time to onset of moderate angina, and the occurrence of a minimum 1.0-mm ST-segment depression were seen following administration of nitroglycerin spray. CONCLUSIONS: These results support the use of sublingual nitroglycerin spray in patients with stable angina who are being managed with medical therapy and in patients who have persistent angina post-revascularization. |
| | |
Authors:
|
Udho Thadani; Thomas Wittig |
Related Documents
:
|
22875719 - Long-term prognostic value of exercise technetium-99m tetrofosmin myocardial perfusion ... 15292739 - Effects of oat beta-glucan on innate immunity and infection after exercise stress. 20303389 - Effects of moderate exercise on cigarette smoke exposure-induced hippocampal oxidative ... 6253239 - Synthetic adrenocorticotropin for optimizing murine circadian chronotolerance for adria... 23521159 - Comparison of dynamic and resting endoscopy of the upper portion of the respiratory tra... 18728639 - Transgene expression, bioactivity, and safety of cere-120 (aav2-neurturin) following de... 8308749 - The effect of epidural anaesthesia with 1% lidocaine on the pressor response to dynamic... 2679269 - Use and misuse of metered-dose inhalers by patients with chronic lung disease. a contro... 18558009 - Incidence of raynaud's phenomenon in relation to hand-arm vibration exposure among male... |
Publication Detail:
|
Type: Journal Article Date: 2012-04-23 |
Journal Detail:
|
Title: Clinical Medicine Insights. Cardiology Volume: 6 ISSN: 1179-5468 ISO Abbreviation: Clin Med Insights Cardiol Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-05-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101525768 Medline TA: Clin Med Insights Cardiol Country: New Zealand |
Other Details:
|
Languages: eng Pagination: 87-95 Citation Subset: - |
Affiliation:
|
Department of Medicine, Cardiovascular Section, University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, OK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Treatment patterns and risk factor control in patients with and without metabolic syndrome in cardia...
Next Document: Incidence and survival of pediatric soft tissue sarcomas in moscow region, Russian Federation, 2000-...