Document Detail

A randomized, double-blind, placebo-controlled study to evaluate the efficacy in AD of liquid soap containing 12% ammonium lactate + 20% urea.
MedLine Citation:
PMID:  19486056     Owner:  NLM     Status:  MEDLINE    
Atopic dermatitis (AD) is a common chronic skin disease, which mainly affects children. Xerosis is one of the most troublesome signs of the disease. The aim of this study was to evaluate the efficacy of liquid soap containing 12% ammonium lactate + 20% urea in patients with AD. In a randomized, double-blind study, 36 patients (both male and female patients; age range 3-40 years) with mild to moderate AD were enrolled. Patients were divided randomly into two groups, in a ratio of 2:1 (active:placebo). The prescribed soap was used on a daily basis during a shower for 3 weeks. All patients continued all other systemic or topical medication but avoided any other soap or emollients. After 3 weeks of treatment, efficacy was assessed both by clinician and patient. There were significant improvements in scaling (P < 0.0001), skin dryness (P < 0.0001) and redness (P = 0.03) as rated by the investigator, and subjective patient assessment of itch also improved (P < 0.001) in the study group compared with the control group. The liquid soap was found to be effective in patients with AD, as use of this soap in patients with stable mild to moderate AD improved the parameters studied.
B Amichai; M H Grunwald
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-05-26
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  34     ISSN:  1365-2230     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-08     Completed Date:  2010-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  e602-4     Citation Subset:  IM    
Department of Dermatology, Sheba Medical Center, Tel. Hashomer, Israel.
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MeSH Terms
Child, Preschool
Dermatitis, Atopic / therapy*
Double-Blind Method
Emollients / chemistry,  therapeutic use*
Lactates / therapeutic use*
Patient Compliance
Quaternary Ammonium Compounds / adverse effects*,  chemistry
Urea / therapeutic use*
Young Adult
Reg. No./Substance:
0/Emollients; 0/Lactates; 0/Quaternary Ammonium Compounds; 57-13-6/Urea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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