Document Detail

A randomized double-blind clinical trial of xipamid and hydrochlorothiazide in essential hypertension.
MedLine Citation:
PMID:  6392119     Owner:  NLM     Status:  MEDLINE    
Seventeen patients with mild to moderate essential hypertension and controlled with antihypertensive drugs were treated with xipamid (40 mg) or hydrochlorothiazide (50 mg) in a double-blind cross-over randomized trial design. After a run-in-period of 2 weeks with placebo, all of them received either of the two drugs. Placebo treatment for 2 weeks decreased both supine as well as standing blood pressure, but it was not statistically significant. Xipamid produced a somewhat greater decrease in blood pressure than hydrochlorothiazide, but the difference was not statistically significant. Similar results were obtained in 12 newly diagnosed cases of mild to moderate essential hypertension treated with xipamid (80 mg) or hydrochlorothiazide (100 mg) daily as single drug treatment in a randomized, double-blind parallel design trial. The side effects produced by both drugs were only mild in nature. No significant changes were produced in serum electrolytes, uric acid and fasting blood glucose in this short term study with either of the drugs.
S Kumar; P Pandhi; P L Wahi; P L Sharma
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  22     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-02-19     Completed Date:  1985-02-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  549-51     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Clinical Trials as Topic
Diuretics / therapeutic use*
Double-Blind Method
Hydrochlorothiazide / adverse effects,  therapeutic use*
Hypertension / drug therapy*
Random Allocation
Xipamide / adverse effects,  therapeutic use*
Reg. No./Substance:
0/Diuretics; 14293-44-8/Xipamide; 58-93-5/Hydrochlorothiazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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