Document Detail


A randomized double-blind clinical trial of xipamid and hydrochlorothiazide in essential hypertension.
MedLine Citation:
PMID:  6392119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seventeen patients with mild to moderate essential hypertension and controlled with antihypertensive drugs were treated with xipamid (40 mg) or hydrochlorothiazide (50 mg) in a double-blind cross-over randomized trial design. After a run-in-period of 2 weeks with placebo, all of them received either of the two drugs. Placebo treatment for 2 weeks decreased both supine as well as standing blood pressure, but it was not statistically significant. Xipamid produced a somewhat greater decrease in blood pressure than hydrochlorothiazide, but the difference was not statistically significant. Similar results were obtained in 12 newly diagnosed cases of mild to moderate essential hypertension treated with xipamid (80 mg) or hydrochlorothiazide (100 mg) daily as single drug treatment in a randomized, double-blind parallel design trial. The side effects produced by both drugs were only mild in nature. No significant changes were produced in serum electrolytes, uric acid and fasting blood glucose in this short term study with either of the drugs.
Authors:
S Kumar; P Pandhi; P L Wahi; P L Sharma
Related Documents :
3566749 - Decreased intracellular free magnesium in erythrocytes of spontaneously hypertensive rats.
6181329 - Endralazine, a new peripheral vasodilator--a randomized cross-over trial against dihydr...
7001489 - Treatment of benign essential hypertension with frusemide in different doses.
11195609 - Combination treatment with telmisartan and hydrochlorothiazide in black patients with m...
1611639 - Multicenter evaluation of the efficacy and safety of sustained-release diltiazem hydroc...
19378589 - Amniotic fluid embolism during vaginal delivery under analgesia. case report.
7127319 - Phase i clinical trial and pharmacokinetics of 4'-carboxyphthalato(1,2-diaminocyclohexa...
1579299 - Bacterial vaginosis: treatment with clindamycin cream versus oral metronidazole.
11966949 - Acute and 7-day portal pressure response to carvedilol and propranolol in cirrhotics.
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  22     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-02-19     Completed Date:  1985-02-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  549-51     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects
Clinical Trials as Topic
Diuretics / therapeutic use*
Double-Blind Method
Humans
Hydrochlorothiazide / adverse effects,  therapeutic use*
Hypertension / drug therapy*
Random Allocation
Xipamide / adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
0/Diuretics; 14293-44-8/Xipamide; 58-93-5/Hydrochlorothiazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  An acrosomal antigen of human spermatozoa and spermatogenic cells characterized with a monoclonal an...
Next Document:  Activation of peritoneal macrophages by berberine-type alkaloids in terms of induction of cytostatic...