Document Detail

A randomized controlled trial of tubal flushing with lipiodol for unexplained infertility.
MedLine Citation:
PMID:  11779610     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the hypothesis that, in couples with unexplained infertility, tubal flushing with an oil-soluble media (lipiodol) would increase the pregnancy rate within 6 months compared with expectant management. DESIGN: A prospective, randomized, controlled study in which couples were allocated to either a single treatment with lipiodol or no further action. SETTING: Two tertiary referral centers for assisted reproduction. PATIENT(S): Couples with a diagnosis of primary or secondary unexplained infertility based on a normal semen analysis according to World Health Organization criteria, patent fallopian tubes at hysterosalpingography or laparoscopy, and ovulatory menstrual cycles based on midluteal phase progesterone levels or ultrasonic follicle tracking. INTERVENTION(S): In those patients randomized to lipiodol, a single treatment was performed. MAIN OUTCOME MEASURE(S): Biochemical (i.e., positive pregnancy test) and clinical (i.e., fetal heart on ultrasound scan) pregnancy rates. RESULT(S): Seventeen couples were randomized to lipiodol and 17 to expectant treatment. The higher pregnancy rate after lipiodol was statistically significant. There were no complications after lipiodol treatment. CONCLUSION(S): There was a statistically significantly higher pregnancy rate in couples with unexplained infertility randomized to a single tubal flush with lipiodol compared with no treatment.
David Nugent; Andrew J Watson; Stephen R Killick; Adam H Balen; Anthony J Rutherford
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Fertility and sterility     Volume:  77     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-07     Completed Date:  2002-02-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  173-5     Citation Subset:  IM    
Centre for Reproduction, Growth and Development, University of Leeds, LGI, Belmont Grove, Leeds, United Kingdom.
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MeSH Terms
Contrast Media / administration & dosage,  therapeutic use
Fallopian Tubes / drug effects*
Infant, Newborn
Infertility, Female / therapy*
Iodized Oil / administration & dosage,  therapeutic use*
Patient Selection
Pregnancy / statistics & numerical data*
Treatment Outcome
Reg. No./Substance:
0/Contrast Media; 8001-40-9/Iodized Oil
Comment In:
Fertil Steril. 2003 Jan;79(1):239-40; author reply 240   [PMID:  12524104 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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