| A randomized controlled trial of thymopentin therapy in patients with chronic hepatitis B. | |
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MedLine Citation:
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PMID: 7836705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Strategies of treatment of chronic hepatitis type B are currently based on the use of either antiviral or immunomodulatory agents. A randomized, controlled trial was performed to assess the safety and efficacy of 6-month thymopentin therapy in 30 patients with chronic hepatitis B. Inclusion criteria were biopsy-proven chronic hepatitis, elevated alanine aminotransferase and serum HBsAg and HBV-DNA positivity for at least 12 months. At the conclusion of the study (1 year), HBV-DNA was negative and alanine aminotransferase had normalized in 13% and 20% of treated cases and in 20% and 27% of controls. None of the ten treated and one of the nine control patients who were initially HBeAg positive subsequently cleared HBeAg. None became HBsAg negative. A histologic improvement was noted in 27% of the treated patients compared with 18% of controls. These results indicate that this regimen of thymopentin therapy is not effective in treating chronic hepatitis B. |
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Authors:
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G Fattovich; G Giustina; A Alberti; M Guido; P Pontisso; S Favarato; L Benvegnù; A Ruol |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hepatology Volume: 21 ISSN: 0168-8278 ISO Abbreviation: J. Hepatol. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1995-02-27 Completed Date: 1995-02-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: DENMARK |
Other Details:
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Languages: eng Pagination: 361-6 Citation Subset: IM |
Affiliation:
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Istituto di Semeiotica e Nefrologia Medica, University of Verona, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alanine Transaminase / blood Chronic Disease DNA, Viral / blood, genetics Dose-Response Relationship, Drug Female Follow-Up Studies Hepatitis B / drug therapy*, epidemiology Hepatitis B Surface Antigens / blood Hepatitis B virus / genetics Humans Male Middle Aged Thymopentin / adverse effects, standards, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral; 0/Hepatitis B Surface Antigens; 69558-55-0/Thymopentin; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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