| A randomized, controlled trial of parenteral glutamine in ill, very low birth-weight neonates. | |
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MedLine Citation:
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PMID: 14581795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The role of "novel substrates" in neonatal nutrition has generated much interest in recent years. Glutamine has been recognized as a "conditionally essential" amino acid in critically ill adults, particularly for gut and immune function; however, its potential role in the neonate remains unclear. The authors examined the safety and benefits of parenteral glutamine in ill, preterm neonates. DESIGN: Randomized controlled trial. METHODS: Thirty-five ill preterm neonates of <1000 g birth-weight were randomized to receive either glutamine-supplemented parenteral nutrition (PN) (n = 17) or standard PN (n = 18). RESULTS: There were no significant differences in birth-weight, gestational age, male-to-female ratio, or Clinical Risk Index for Babies (CRIB) score between the two groups. During PN there were no significant differences between the groups in white cell count, differential white cell count, blood urea nitrogen, plasma ammonia, lactate, pyruvate, plasma glutamine, or glutamate. The median time to achieving full enteral nutrition (FEN) was shorter in the study group (13 days vs. 21 days, P < 0.05). The number of episodes of culture-positive sepsis or age at discharge did not differ between groups. CONCLUSIONS: Parenteral glutamine appears to be well tolerated and safe in the ill, preterm neonate. It may reduce the time to achieving FEN. |
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Authors:
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S W Thompson; B G McClure; T R J Tubman |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 37 ISSN: 0277-2116 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-10-28 Completed Date: 2004-03-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 550-3 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Craigavon Area Hospital, County Armagh, Northern Ireland. STHOMPSON@cahgt.n-i.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood Ammonia / blood Birth Weight Enteral Nutrition Female Gestational Age Glutamine / administration & dosage*, blood Humans Infant Nutritional Physiological Phenomena Infant, Newborn Infant, Premature* Infant, Very Low Birth Weight* Lactic Acid / blood Liver Function Tests Male Parenteral Nutrition* Pyruvic Acid / blood Risk Factors Time Factors Urea / blood |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 56-85-9/Glutamine; 57-13-6/Urea; 7664-41-7/Ammonia |
| Comments/Corrections | |
Comment In:
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J Pediatr Gastroenterol Nutr. 2003 Nov;37(5):533-5
[PMID:
14581791
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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