Document Detail


A randomized, controlled trial of parenteral glutamine in ill, very low birth-weight neonates.
MedLine Citation:
PMID:  14581795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The role of "novel substrates" in neonatal nutrition has generated much interest in recent years. Glutamine has been recognized as a "conditionally essential" amino acid in critically ill adults, particularly for gut and immune function; however, its potential role in the neonate remains unclear. The authors examined the safety and benefits of parenteral glutamine in ill, preterm neonates. DESIGN: Randomized controlled trial. METHODS: Thirty-five ill preterm neonates of <1000 g birth-weight were randomized to receive either glutamine-supplemented parenteral nutrition (PN) (n = 17) or standard PN (n = 18). RESULTS: There were no significant differences in birth-weight, gestational age, male-to-female ratio, or Clinical Risk Index for Babies (CRIB) score between the two groups. During PN there were no significant differences between the groups in white cell count, differential white cell count, blood urea nitrogen, plasma ammonia, lactate, pyruvate, plasma glutamine, or glutamate. The median time to achieving full enteral nutrition (FEN) was shorter in the study group (13 days vs. 21 days, P < 0.05). The number of episodes of culture-positive sepsis or age at discharge did not differ between groups. CONCLUSIONS: Parenteral glutamine appears to be well tolerated and safe in the ill, preterm neonate. It may reduce the time to achieving FEN.
Authors:
S W Thompson; B G McClure; T R J Tubman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  37     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-10-28     Completed Date:  2004-03-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  550-3     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Craigavon Area Hospital, County Armagh, Northern Ireland. STHOMPSON@cahgt.n-i.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / blood
Ammonia / blood
Birth Weight
Enteral Nutrition
Female
Gestational Age
Glutamine / administration & dosage*,  blood
Humans
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature*
Infant, Very Low Birth Weight*
Lactic Acid / blood
Liver Function Tests
Male
Parenteral Nutrition*
Pyruvic Acid / blood
Risk Factors
Time Factors
Urea / blood
Chemical
Reg. No./Substance:
0/Amino Acids; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 56-85-9/Glutamine; 57-13-6/Urea; 7664-41-7/Ammonia
Comments/Corrections
Comment In:
J Pediatr Gastroenterol Nutr. 2003 Nov;37(5):533-5   [PMID:  14581791 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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