Document Detail

A randomized, controlled trial of octreotide in the management of patients with acute pancreatitis.
MedLine Citation:
PMID:  9127169     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: In this study, octreotide was not found to be of benefit in the treatment of acute pancreatitis. BACKGROUND: Somatostatin and its long-acting analog octreotide have both been proposed for the treatment of patients with acute pancreatitis, but neither agent has been adequately assessed in patients with severe attacks. METHODS: Fifty-eight patients with moderate or severe acute pancreatitis who were admitted to hospitals within the west of Scotland over an 18-mo period were randomized to receive octreotide, 40 micrograms/h, by continuous i.v. infusion for 5 d, or placebo in addition to standard supportive therapy. RESULTS: There was no significant difference in the incidence of complications (54% octreotide group and 40% placebo group) or mortality (octreotide group 18%; placebo group 20%).
C McKay; J Baxter; C Imrie
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of pancreatology : official journal of the International Association of Pancreatology     Volume:  21     ISSN:  0169-4197     ISO Abbreviation:  Int. J. Pancreatol.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-06-19     Completed Date:  1997-06-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8703511     Medline TA:  Int J Pancreatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  13-9     Citation Subset:  IM    
Department of Surgery, Glasgow Royal Infirmary, UK.
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MeSH Terms
Acute Disease
Aged, 80 and over
Middle Aged
Octreotide / adverse effects,  therapeutic use*
Pancreatitis / drug therapy*,  mortality
Reg. No./Substance:

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