| A randomized controlled trial of interferon alfa-2b as therapy for chronic non-A, non-B hepatitis. | |
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MedLine Citation:
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PMID: 2127787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eighty patients with chronic non-A, non-B hepatitis completed a randomized controlled trial of the therapeutic efficacy of recombinant interferon alfa-2b. Twenty-nine received 1 million units and 26 received 3 million units of interferon subcutaneously thrice weekly for 6 months, and 25 were controls. Normalization or a significant decrease of alanine aminotransferase values was obtained in 19/29 (66%) patients treated with 1 million units, in 18/26 (69%) patients treated with 3 million units and in one control patient (4%, p less than 0.05). However, when control patients were randomized after the initial 24 weeks to receive 1 or 3 million units of interferon for 48 weeks, 12/14 (86%) patients receiving 3 million units responded to therapy versus 3/11 patients receiving 1 million units (27%, p less than 0.05). After a 1 to 6 months follow-up period post treatment, an alanine aminotransferase relapse was observed in 18/30 (60%) responders to 3 million units and in 17/22 (77%) responders to 1 million units. Cirrhotic patients responded less than patients with non-cirrhotic disease (47 vs. 78%, p less than 0.05). Only responders treated with 3 million units significantly ameliorated their histologic picture (pre-therapy Knodell's index = 8.9, post-therapy = 6.0, p less than 0.05). The data confirm that treatment with interferon is of benefit in patients with chronic non-A, non-B hepatitis. |
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Authors:
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G Saracco; F Rosina; M R Torrani Cerenzia; V Lattore; L Chiandussi; V Gallo; R Petrino; A G De Micheli; E Donegani; A Solinas |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of hepatology Volume: 11 Suppl 1 ISSN: 0168-8278 ISO Abbreviation: J. Hepatol. Publication Date: 1990 |
Date Detail:
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Created Date: 1991-04-30 Completed Date: 1991-04-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8503886 Medline TA: J Hepatol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: S43-9 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Molinette Hospital, Turin, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alanine Transaminase / blood Chronic Disease Female Hepatitis C / blood, pathology, therapy* Humans Interferon Alfa-2b / therapeutic use* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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99210-65-8/Interferon Alfa-2b; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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