Document Detail

A randomized controlled trial of the effect of alcohol consumption on blood pressure.
MedLine Citation:
PMID:  4028514     Owner:  NLM     Status:  MEDLINE    
Forty-six healthy normotensive male drinkers participated in a randomized, controlled, crossover trial to study the effects of varying alcohol intake on blood pressure. Alcohol consumption (calculated from weekly diaries) was reduced from 336.3 (s.e.m. = 20.2) to 64.5 (s.e.m. = 5.6) ml ethanol/week by drinking low alcohol content beer alone. Systolic blood pressure fell significantly during reduction of alcohol intake and rose again when normal drinking habits were resumed, the mean difference during the last 2 weeks of normal or low alcohol intake being 3.8 mmHg. This effect of alcohol on blood pressure was independent of a small but significant decrease in weight following reduction of alcohol intake. The change in blood pressure correlated with change in alcohol consumption (r = 0.53, P less than 0.001) with a 1 mmHg fall predicted for each 100 ml of reduction in ethanol intake/week. We conclude that regular moderate alcohol consumption has a direct (but reversible) pressor effect in normotensive men.
I B Puddey; L J Beilin; R Vandongen; I L Rouse
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  12     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1985 May-Jun
Date Detail:
Created Date:  1985-10-15     Completed Date:  1985-10-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  257-61     Citation Subset:  IM    
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MeSH Terms
Alcohol Drinking*
Blood Pressure / drug effects*
Middle Aged
Random Allocation
Regression Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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