Document Detail


A randomized controlled trial of early surgery in Duchenne muscular dystrophy.
MedLine Citation:
PMID:  1300186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We performed a randomized controlled trial of early surgical treatment of contractures in 20 boys with Duchenne muscular dystrophy, age 4-6 yr. Surgery consisted of release of hip flexors, removal of iliotibial bands, and lengthening of tendo Achilles bilaterally. All patients were monitored for at least 12 months post-randomization, and assessed quantitatively for muscle strength and function. Surgery corrected the deformities, but had no beneficial effect on strength or function. Indeed, data in the second year showed more rapid deterioration of function in some of the operated boys. There appeared to be continued evolution of pathology following surgery, as assessed by sequential muscle ultrasound and muscle biopsy. We cannot recommend this type of surgery as a routine treatment.
Authors:
A Y Manzur; S A Hyde; E Rodillo; J Z Heckmatt; G Bentley; V Dubowitz
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuromuscular disorders : NMD     Volume:  2     ISSN:  0960-8966     ISO Abbreviation:  Neuromuscul. Disord.     Publication Date:  1992  
Date Detail:
Created Date:  1993-05-27     Completed Date:  1993-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9111470     Medline TA:  Neuromuscul Disord     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  379-87     Citation Subset:  IM    
Affiliation:
Hammersmith Neuromuscular Centre, Department of Paediatrics, Royal Postgraduate Medical School, London, U.K.
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Child
Child, Preschool
Follow-Up Studies
Gait
Hip Joint / surgery*
Humans
Leg / surgery*
Male
Muscle Contraction / physiology
Muscles / pathology,  ultrasonography
Muscular Dystrophies / pathology,  physiopathology,  surgery*,  ultrasonography
Regression Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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