Document Detail

A randomized controlled trial of dietary fat reduction: the retention of subjects and characteristics of drop outs.
MedLine Citation:
PMID:  1738009     Owner:  NLM     Status:  MEDLINE    
We have examined the feasibility of carrying out a randomized controlled trial of dietary fat reduction in women at increased risk for breast cancer. The randomization was either to a control group who were taught the principles of balanced nutrition, but were not counselled to change their fat intake, or to an intervention group who were taught to reduce their dietary fat intake to 15% of total calories from a baseline average of 35% of calories. Potentially eligible subjects were women attending a breast diagnostic clinic who had the mammographic pattern of dysplasia. Subjects were recruited by letter from their referring surgeon followed by a telephone call. Subjects interested in participating in the study then entered by one of two phases. In Phase I, the study was explained, informed consent sought and willing subjects randomized to the intervention or control group. Using this procedure 227 subjects were randomized and 48 (21%) dropped out of the study in the 12 months following randomization. (A drop out was defined as a subject who persistently failed to keep appointments and provide nutrient data.) Of these drop outs, 30 (63%) occurred at or soon after randomization. A modified procedure of entry was then adopted in which subjects interested in the study were first taught the procedures involved, including keeping food records and clinic appointments, and were then asked to provide consent and randomized. Two hundred and eighty subjects were enrolled using this modified procedure and 25 (9%) have dropped out in the 12 months following randomization.(ABSTRACT TRUNCATED AT 250 WORDS)
N F Boyd; M Cousins; V Kriukov
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical epidemiology     Volume:  45     ISSN:  0895-4356     ISO Abbreviation:  J Clin Epidemiol     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-03-19     Completed Date:  1992-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8801383     Medline TA:  J Clin Epidemiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  IM    
Division of Epidemiology and Statistics, Ontario Cancer Institute, Toronto, Canada.
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MeSH Terms
Body Height
Body Weight
Breast Diseases / diet therapy,  psychology*,  radiography
Dietary Fats / administration & dosage*
Feasibility Studies
Nutrition Surveys
Patient Compliance / psychology*
Patient Dropouts / psychology*
Reg. No./Substance:
0/Dietary Fats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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