Document Detail


A randomized controlled trial comparing powdery sublingual misoprostol and sublingual misoprostol tablet for management of embryonic death or anembryonic pregnancy.
MedLine Citation:
PMID:  19190928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To compare complete abortion rate, duration of abortion, and side effects between 600 microg powdery sublingual misoprostol and 600 microg sublingual misoprostol tablet for management of embryonic death or anembryonic pregnancy. MATERIALS AND METHODS: Fifty-four pregnant women up to 13 weeks of gestation diagnosed with embryonic death or anembryonic pregnancy were randomized to receive 600 microg powdery sublingual misoprostol or 600 microg sublingual misoprostol tablet. Complete abortion was evaluated by transvaginal ultrasound at 48 h. RESULTS: Twenty-six patients received 600 microg powdery sublingual misoprostol and 28 patients received 600 microg sublingual misoprostol tablet. Complete abortion rate was 34.6% in powdery sublingual misoprostol group and 32.1% in sublingual misoprostol tablet group (P = 0.847). Duration of abortion in powdery sublingual misoprostol group and sublingual misoprostol tablet group was similar (34.7 +/- 18.8 vs. 36.9 +/- 17.8 h, respectively, P = 0.656). There was no significant difference in the side effects between both groups. CONCLUSIONS: Single dose of 600 microg of powdery sublingual misoprostol does not improve its efficacy for management of embryonic death or anembryonic pregnancy when compared to sublingual misoprostol tablet.
Authors:
Chatawan Saichua; Vorapong Phupong
Related Documents :
12452468 - A randomised study of misoprostol and gemeprost in combination with mifepristone for in...
12959148 - Early medical termination pregnancy with methotrexate and misoprostol in lower segment ...
12517648 - A randomized trial of oral and vaginal misoprostol to manage delivery in cases of fetal...
2050808 - Mechanism of the insertion of actin monomers between the barbed ends of actin filaments...
10355378 - Estimates of the annual number of clinically recognized pregnancies in the united state...
23726968 - Difference in the d-dimer rise between women with singleton and multifetal pregnancies.
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2009-02-04
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  280     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-07-24     Completed Date:  2009-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  431-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Pathumwan, Bangkok, Thailand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents, Nonsteroidal / administration & dosage*
Abortion, Induced / methods
Administration, Sublingual
Adult
Embryo Loss / drug therapy*,  ultrasonography
Female
Humans
Misoprostol / administration & dosage*
Powders
Pregnancy
Pregnancy Complications / drug therapy*,  ultrasonography
Tablets
Young Adult
Chemical
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Powders; 0/Tablets; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The efficacy of Implanon for the treatment of chronic pelvic pain associated with pelvic congestion:...
Next Document:  Alterations of epithelial adhesion molecules and basement membrane components in lattice corneal dys...