Document Detail

A randomized controlled trial comparing the efficacy and acceptability of phospo-soda buffered saline (Fleet) with sodium picosulphate/magnesium citrate (Picoprep) in the preparation of patients for colonoscopy.
MedLine Citation:
PMID:  17868404     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Small-volume bowel preparations for colonoscopy has become increasingly popular due to improved tolerance by patients and equivalent efficacy compared with the larger volume preparations. Comparative studies, however, between small volume preparations are lacking. This randomized controlled trial aimed at comparing the efficacy and acceptability of phospo-soda buffered saline (Fleet) with sodium picosulphate/magnesium citrate (Picoprep) in the preparation of patients for colonoscopy. METHOD: A randomized prospective trial designed to compare the efficacy and acceptability of Fleet with Picoprep in patients undergoing colonoscopy. RESULTS: Seventy-three patients undergoing colonoscopy were randomized to receive either Fleet or Picoprep as bowel preparation. Patients were asked to score the acceptability and to comment specifically on adverse events, namely headache, nausea and vomiting. The efficacy of the preparation was also assessed. The results showed no difference in efficacy (P = 0.06, chi(2) test), but there was a significant difference in acceptability (P = 0.01, chi(2) test). and side effects of patients suffering nausea (P = 0.003, chi(2) test), in favour of Picoprep. CONCLUSION: Whilst there was no difference in efficacy, there was a significant difference in acceptability and side effects in favour of Picoprep.
A J Renaut; S Raniga; F A Frizelle; R E Perry; L Guilford
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2007-09-13
Journal Detail:
Title:  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland     Volume:  10     ISSN:  1463-1318     ISO Abbreviation:  Colorectal Dis     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-15     Completed Date:  2008-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883611     Medline TA:  Colorectal Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  503-5     Citation Subset:  IM    
The Oxford Clinic, Christchurch, New Zealand.
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MeSH Terms
Cathartics* / adverse effects
Citric Acid* / adverse effects
Organometallic Compounds* / adverse effects
Patient Acceptance of Health Care*
Phosphates* / adverse effects
Picolines* / adverse effects
Prospective Studies
Treatment Outcome
Reg. No./Substance:
0/Cathartics; 0/Organometallic Compounds; 0/Phosphates; 0/Picolines; 0/magnesium citrate; 10040-45-6/picosulfate sodium; 7632-05-5/sodium phosphate; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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