Document Detail


A randomized, controlled trial of artemisinin-piperaquine vs dihydroartemisinin-piperaquine phosphate in treatment of falciparum malaria.
MedLine Citation:
PMID:  19568711     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The study aimed to evaluate and compare the efficacy and safety of dihydroartemisinin-piperaquine phosphate (Artekin) and artemisinin-piperaquine (Artequick) in the treatment of uncomplicated falciparum malaria. METHODS: A total of 103 uncomplicated falciparum malaria patients were enrolled and randomly assigned to two groups: 52 cases in the Artequick group, and 51 cases in the Artekin group. The patients in the Artequick group were administered with Artequick, twice in 24 h, whereas the patients in the Artekin group were given Artekin 4 times in 2 days. The mean parasite clearance time, mean fever clearance time, 28-day cure rate and parasite recrudescence rates of the two groups were then compared. RESULTS: The mean parasite clearance time and the mean fever clearance time were 43.2+/-13.9 h and 24.7+/-9.9 h, in the Artequick group, and 36.5+/-17.1 h and 22.7+/-11.2 h, in the Artekin group. In both groups the 28-day cure rate was 100%, and the parasite recrudescence rate was 0. CONCLUSION: Both medicines had high cure rates, low recrudescence rates, and no serious adverse reactions. The administration of Artequick, however, was more convenient and lower incidence of gastrointestinal side effects than that of Artekin, so as to increase the efficacy in the malaria population.
Authors:
Trieu Nguyen Trung; Bo Tan; Dang Van Phuc; Jian-ping Song
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-07-02
Journal Detail:
Title:  Chinese journal of integrative medicine     Volume:  15     ISSN:  1672-0415     ISO Abbreviation:  Chin J Integr Med     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-07-01     Completed Date:  2009-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101181180     Medline TA:  Chin J Integr Med     Country:  China    
Other Details:
Languages:  eng     Pagination:  189-92     Citation Subset:  IM    
Affiliation:
Institute of Malariology, Parasitology and Entomology-Qui Nhon, Ministry of Health, Vietnam.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anti-Infective Agents / administration & dosage*,  adverse effects
Antimalarials / administration & dosage*
Artemisinins / administration & dosage*,  adverse effects
Drug Combinations
Female
Humans
Integrative Medicine
Malaria, Falciparum / drug therapy*
Male
Quinolines / administration & dosage*,  adverse effects
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Antimalarials; 0/Artemisinins; 0/Drug Combinations; 0/Quinolines; 4085-31-8/piperaquine; 63968-64-9/artemisinine; 71939-50-9/dihydroquinghaosu

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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