Document Detail

A randomized, controlled trial of aerobic exercise in combination with paroxetine in the treatment of panic disorder.
MedLine Citation:
PMID:  20602575     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Regular aerobic exercise (running) has been shown to be superior to a pill placebo in the treatment of panic disorder. Combined drug and exercise treatment has not been investigated in randomized controlled studies to date.
METHODS: This is a randomized, 10-week, controlled, parallel group, pilot study. A total of 75 outpatients with panic disorder with or without agoraphobia (DSM-IV and ICD-10) received either (1) exercise plus paroxetine 40 mg/day (n=21), (2) relaxation plus paroxetine (n=17), (3) exercise plus pill placebo (n=20), or (4) relaxation plus pill placebo (n=17). Changes in the Panic and Agoraphobia Scale (P&A), and the Clinical Global Impression Scale (CGI) underwent repeated measure analysis.
RESULTS: Effects sizes were large for all groups (d=1.53-3.87), however not significantly different. Paroxetine-treated patients were significantly more improved than placebo-treated patients. On the CGI, patients in the exercise groups (plus paroxetine or placebo) had a trend toward better improvement compared to relaxation (P=0.06). Response and remission rates were higher in the paroxetine compared to pill placebo groups.
CONCLUSIONS: While paroxetine was superior to placebo, aerobic exercise did not differ from relaxation training in most efficacy measures.
Dirk Wedekind; Andreas Broocks; Nina Weiss; Kirsten Engel; Karin Neubert; Borwin Bandelow
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry     Volume:  11     ISSN:  1814-1412     ISO Abbreviation:  World J. Biol. Psychiatry     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-24     Completed Date:  2011-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120023     Medline TA:  World J Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  904-13     Citation Subset:  IM    
Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany.
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MeSH Terms
Agoraphobia / diagnosis,  psychology,  therapy*
Combined Modality Therapy
Middle Aged
Panic Disorder / diagnosis,  psychology,  therapy*
Paroxetine / therapeutic use*
Pilot Projects
Relaxation Therapy
Running / psychology*
Serotonin Uptake Inhibitors / therapeutic use*
Young Adult
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 61869-08-7/Paroxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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