Document Detail


A randomized controlled trial of NuvaRing versus combined oral contraceptive pills for pretreatment in in vitro fertilization cycles.
MedLine Citation:
PMID:  21880278     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether use of the NuvaRing (Merck) for pretreatment in IVF cycles would result in better cycle control and patient satisfaction versus a 30-μg oral contraceptive (OC) pill.
DESIGN: A prospective randomized, controlled study.
SETTING: An academic, hospital-based fertility clinic in Toronto, Canada.
PATIENT(S): Patients 18-37 years old, undergoing their first IVF or IVF/intracytoplasmic sperm injection (ICSI) cycle.
INTERVENTION(S): OC versus NuvaRing for IVF pre-treatment.
MAIN OUTCOME MEASURE(S): Patient satisfaction, ovarian suppression, and IVF cycle outcomes.
RESULT(S): Demographic data were similar in both groups. There were no significant differences in side effects between the NuvaRing and OC pill group with the exception of more breast discomfort in the OC pill group. There were no differences in the protocols, days of stimulation, and number of oocytes between the groups. Patients in the OC pill group had more embryos on day 3 and more patients had excess embryos for freezing. The number of embryos transferred and clinical pregnancy rates (PR) were similar between the two groups, although more patients in the NuvaRing group had cycles cancelled for poor stimulation.
CONCLUSION(S): There was no significant benefit in patient tolerability or side effects with the NuvaRing versus the OC pill for IVF pretreatment; however, side effects overall were low in both groups. Clinical PRs were similar; however, the NuvaRing group had more cancelled cycles and fewer excess embryos for freezing.
CLINICAL TRIAL REGISTRATION: #NCT01298128.
Authors:
Kimberly E Liu; Munirah Alhajri; Ellen Greenblatt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  96     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  605-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Centre for Fertility and Reproductive Health, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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