| A randomized, controlled study of amiodarone for prevention of atrial fibrillation after transthoracic esophagectomy. | |
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MedLine Citation:
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PMID: 20381077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Atrial fibrillation is common after esophagectomy. The objective of this study was to determine the efficacy and safety of amiodarone for prevention of atrial fibrillation after transthoracic esophagectomy. METHODS: Eighty patients undergoing transthoracic esophagectomy were randomly, prospectively assigned to receive amiodarone (n = 40) or no prophylaxis (control group, n = 40). Amiodarone-treated patients received the drug by continuous infusion, initiated at the time of induction of anesthesia, at a rate of 0.73 mg/min (43.75 mg/h), and continued for 96 hours (total dose 4200 mg). The primary end point was atrial fibrillation requiring treatment. Secondary end points included any atrial fibrillation lasting longer than 30 seconds and postoperative hospital and intensive care unit stays. RESULTS: There were no significant differences between the amiodarone and control groups in demographic characteristics, comorbid conditions, or preoperative or postoperative use of beta-blockers or calcium-channel blockers. The incidence of atrial fibrillation requiring treatment was lower in the amiodarone group than in the control group (15% vs 40%, P = .02, relative risk reduction 62.5%). There were no significant differences between the amiodarone and control groups in median hospital stay (11 days vs 12 days, P = .31) or median intensive care unit stay (68 hours vs 77 hours, p = .097). There were no significant difference between the groups in the incidences of adverse effects. CONCLUSIONS: Amiodarone prophylaxis significantly reduced the incidence of atrial fibrillation after transthoracic esophagectomy. |
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Authors:
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James E Tisdale; Heather A Wroblewski; Donna S Wall; Karen M Rieger; Zane T Hammoud; Jerry V Young; Kenneth A Kesler |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-04-09 |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 140 ISSN: 1097-685X ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 45-51 Citation Subset: AIM; IM |
Copyright Information:
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2010 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Pharmacy Practice, School of Pharmacy & Pharmaceutical Sciences, Purdue University, Indianapolis, Ind 46202, USA. jtisdale@iupui.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amiodarone / administration & dosage*, adverse effects, analogs & derivatives, blood Anti-Arrhythmia Agents / administration & dosage*, adverse effects, blood Atrial Fibrillation / etiology, prevention & control* Chi-Square Distribution Drug Administration Schedule Esophagectomy / adverse effects*, methods, mortality Female Humans Incidence Indiana Infusions, Intravenous Intensive Care Kaplan-Meiers Estimate Length of Stay Male Middle Aged Prospective Studies Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone; 83409-32-9/desethylamiodarone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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