| A randomized controlled evaluation of absorption of silver with the use of silver alginate (Algidex) patches in very low birth weight (VLBW) infants with central lines. | |
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MedLine Citation:
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PMID: 19940856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To measure systemic silver absorption when using silver-impregnated alginate central catheter dressings in very low birth weight (VLBW) neonates and to monitor blood stream infection. STUDY DESIGN: Fifty infants were enrolled in a prospective, randomized controlled trial lasting 28 days. Each patient was assigned to standard dressing or silver alginate (Algidex) group. Serum silver concentrations were obtained on day 1, 7, and 28. RESULT: Significant differences in mean serum silver concentrations for the treatment versus standard dressing group were observed using student's t-test analysis. The silver alginate group had a 45.8% reduction in infection/1000 line days, although too few patients were enrolled to draw meaningful efficacy conclusions about prevention of blood stream infection. CONCLUSION: Mean serum silver concentrations in the treatment group were significantly higher than controls although below levels anticipated to result in toxicity. A large study evaluating reduced blood stream infections in VLBW infants is warranted. |
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Authors:
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A Z Khattak; R Ross; T Ngo; C T Shoemaker |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2009-11-26 |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: 30 ISSN: 1476-5543 ISO Abbreviation: J Perinatol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-29 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 337-42 Citation Subset: IM |
Affiliation:
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Department of Neonatology, Baylor University Medical Center, Dallas, TX 75246, USA. AsifK@baylorhealth.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Anti-Infective Agents, Local / administration & dosage, pharmacokinetics* Bacteremia / blood*, epidemiology, prevention & control Bandages* Catheter-Related Infections / blood*, epidemiology, prevention & control Catheterization, Central Venous* / adverse effects Catheters, Indwelling / adverse effects Cohort Studies Female Humans Infant, Newborn Infant, Very Low Birth Weight Male Pilot Projects Polysaccharides Polyurethanes Silver Compounds / administration & dosage, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 0/Polysaccharides; 0/Polyurethanes; 0/Silver Compounds; 9009-54-5/polyurethane foam; 9050-36-6/maltodextrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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