Document Detail


A randomized controlled evaluation of absorption of silver with the use of silver alginate (Algidex) patches in very low birth weight (VLBW) infants with central lines.
MedLine Citation:
PMID:  19940856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To measure systemic silver absorption when using silver-impregnated alginate central catheter dressings in very low birth weight (VLBW) neonates and to monitor blood stream infection. STUDY DESIGN: Fifty infants were enrolled in a prospective, randomized controlled trial lasting 28 days. Each patient was assigned to standard dressing or silver alginate (Algidex) group. Serum silver concentrations were obtained on day 1, 7, and 28. RESULT: Significant differences in mean serum silver concentrations for the treatment versus standard dressing group were observed using student's t-test analysis. The silver alginate group had a 45.8% reduction in infection/1000 line days, although too few patients were enrolled to draw meaningful efficacy conclusions about prevention of blood stream infection. CONCLUSION: Mean serum silver concentrations in the treatment group were significantly higher than controls although below levels anticipated to result in toxicity. A large study evaluating reduced blood stream infections in VLBW infants is warranted.
Authors:
A Z Khattak; R Ross; T Ngo; C T Shoemaker
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-11-26
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  30     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-29     Completed Date:  2010-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  337-42     Citation Subset:  IM    
Affiliation:
Department of Neonatology, Baylor University Medical Center, Dallas, TX 75246, USA. AsifK@baylorhealth.edu
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Anti-Infective Agents, Local / administration & dosage,  pharmacokinetics*
Bacteremia / blood*,  epidemiology,  prevention & control
Bandages*
Catheter-Related Infections / blood*,  epidemiology,  prevention & control
Catheterization, Central Venous* / adverse effects
Catheters, Indwelling / adverse effects
Cohort Studies
Female
Humans
Infant, Newborn
Infant, Very Low Birth Weight
Male
Pilot Projects
Polysaccharides
Polyurethanes
Silver Compounds / administration & dosage,  pharmacokinetics*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Polysaccharides; 0/Polyurethanes; 0/Silver Compounds; 9009-54-5/polyurethane foam; 9050-36-6/maltodextrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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