Document Detail


A randomized controlled double-blind study of the effects on hemostasis of two progestogen-only pills containing 75 microgram desogestrel or 30 microgram levonorgestrel.
MedLine Citation:
PMID:  9693398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of two progestogen-only pills containing either 75 microgram desogestrel (DSG) or 30 microgram levonorgestrel (LNG) on hemostasis were investigated in a double-blind, randomized, controlled study of seven treatment cycles in 78 healthy women. DSG reduced factor VII activity (p < 0.05) and prothrombin fragment 1+2 (p < 0.05) and increased protein S (p < 0.001). LNG reduced factor VII activity (p < 0.01) and plasminogen activity (p < 0.01) and increased tissue-plasminogen activator (t-PA) (p < 0.05). At the end of the post-treatment cycle with DSG, protein S (p < 0.01) and t-PA (p < 0.05) were increased and plasminogen activity was decreased (p < 0.05), whereas with LNG, t-PA was increased (p < 0.001) and prothrombin fragment 1+2 (p < 0.05) and plasminogen activity (p < 0.001) were decreased. Between-group comparisons revealed higher values for DSG regarding the anticoagulatory parameter protein S at cycle 7 (p < 0.01) and post-treatment assessments (p < 0.05), and the fibrinolytic parameter plasmin-antiplasmin complex was higher with DSG at cycle 7 (p < 0.05) and at post-treatment (p < 0.05). Both preparations had comparable and potentially favorable effects of hemostasis, and may offer suitable hormonal contraception to women with a personal or family history of venous thromboembolic diseases.
Authors:
U H Winkler; H Howie; K Bühler; T Korver; T B Geurts; H J Coelingh Bennink
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contraception     Volume:  57     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-10-15     Completed Date:  1998-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  385-92     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, University Hospital of Essen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Contraceptives, Oral, Synthetic*
Desogestrel / adverse effects*
Double-Blind Method
Factor VII / metabolism
Female
Fibrin Fibrinogen Degradation Products / metabolism
Fibrinolysis
Hemostasis*
Humans
Levonorgestrel / adverse effects*
Peptide Fragments / metabolism
Plasminogen / metabolism
Plasminogen Activator Inhibitor 1 / metabolism
Progesterone Congeners*
Protein S / metabolism
Prothrombin / metabolism
Chemical
Reg. No./Substance:
0/Contraceptives, Oral, Synthetic; 0/Fibrin Fibrinogen Degradation Products; 0/Peptide Fragments; 0/Plasminogen Activator Inhibitor 1; 0/Progesterone Congeners; 0/Protein S; 0/fibrin fragment D; 0/prothrombin fragment 1.2; 54024-22-5/Desogestrel; 797-63-7/Levonorgestrel; 9001-25-6/Factor VII; 9001-26-7/Prothrombin; 9001-91-6/Plasminogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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