| A randomized controlled double-blind study of the effects on hemostasis of two progestogen-only pills containing 75 microgram desogestrel or 30 microgram levonorgestrel. | |
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MedLine Citation:
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PMID: 9693398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of two progestogen-only pills containing either 75 microgram desogestrel (DSG) or 30 microgram levonorgestrel (LNG) on hemostasis were investigated in a double-blind, randomized, controlled study of seven treatment cycles in 78 healthy women. DSG reduced factor VII activity (p < 0.05) and prothrombin fragment 1+2 (p < 0.05) and increased protein S (p < 0.001). LNG reduced factor VII activity (p < 0.01) and plasminogen activity (p < 0.01) and increased tissue-plasminogen activator (t-PA) (p < 0.05). At the end of the post-treatment cycle with DSG, protein S (p < 0.01) and t-PA (p < 0.05) were increased and plasminogen activity was decreased (p < 0.05), whereas with LNG, t-PA was increased (p < 0.001) and prothrombin fragment 1+2 (p < 0.05) and plasminogen activity (p < 0.001) were decreased. Between-group comparisons revealed higher values for DSG regarding the anticoagulatory parameter protein S at cycle 7 (p < 0.01) and post-treatment assessments (p < 0.05), and the fibrinolytic parameter plasmin-antiplasmin complex was higher with DSG at cycle 7 (p < 0.05) and at post-treatment (p < 0.05). Both preparations had comparable and potentially favorable effects of hemostasis, and may offer suitable hormonal contraception to women with a personal or family history of venous thromboembolic diseases. |
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Authors:
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U H Winkler; H Howie; K Bühler; T Korver; T B Geurts; H J Coelingh Bennink |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Contraception Volume: 57 ISSN: 0010-7824 ISO Abbreviation: Contraception Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-10-15 Completed Date: 1998-10-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0234361 Medline TA: Contraception Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 385-92 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, University Hospital of Essen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Contraceptives, Oral, Synthetic* Desogestrel / adverse effects* Double-Blind Method Factor VII / metabolism Female Fibrin Fibrinogen Degradation Products / metabolism Fibrinolysis Hemostasis* Humans Levonorgestrel / adverse effects* Peptide Fragments / metabolism Plasminogen / metabolism Plasminogen Activator Inhibitor 1 / metabolism Progesterone Congeners* Protein S / metabolism Prothrombin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral, Synthetic; 0/Fibrin Fibrinogen Degradation Products; 0/Peptide Fragments; 0/Plasminogen Activator Inhibitor 1; 0/Progesterone Congeners; 0/Protein S; 0/fibrin fragment D; 0/prothrombin fragment 1.2; 54024-22-5/Desogestrel; 797-63-7/Levonorgestrel; 9001-25-6/Factor VII; 9001-26-7/Prothrombin; 9001-91-6/Plasminogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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