| A randomized controlled comparison of the efficacy of Dead Sea salt balneophototherapy vs. narrowband ultraviolet B monotherapy for chronic plaque psoriasis. | |
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MedLine Citation:
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PMID: 16120152 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Dead Sea (DS) salt solution soaks are used in combination with narrowband ultraviolet B (NB-UVB) to treat psoriasis in many centres, particularly in continental Europe. No previously published controlled study has assessed DS salt + NB-UVB balneophototherapy. OBJECTIVES: To compare DS salt balneophototherapy with NB-UVB monotherapy for chronic plaque psoriasis. METHODS: Sixty patients with chronic plaque psoriasis participated in this paired, controlled study, with pretreatment DS salt soaks randomly allocated to each participant's right or left study limb. Psoriasis severity was assessed with a Scaling, Erythema and Induration score by a blinded observer. Assessments were weekly during the therapy course, and thereafter 8-weekly until relapse or for up to 1 year after clearance. RESULTS: The mean area under the psoriasis severity-time curves during treatment was not detectably lower with DS salt balneophototherapy than with NB-UVB monotherapy (P = 0.099). The psoriasis severity score fell slightly more from beginning to end of courses with DS salt balneophototherapy than with NB-UVB monotherapy (P = 0.019). There was no detectable difference in times to relapse. CONCLUSIONS: In this population the addition of pretreatment DS salt soaks to NB-UVB did not result in a clinically important improvement in clearance of psoriasis. |
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Authors:
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R S Dawe; S Yule; H Cameron; H Moseley; S H Ibbotson; J Ferguson |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of dermatology Volume: 153 ISSN: 0007-0963 ISO Abbreviation: Br. J. Dermatol. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-25 Completed Date: 2005-11-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 613-9 Citation Subset: IM |
Affiliation:
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Photobiology Unit, Department of Dermatology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. r.s.dawe@dundee.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Area Under Curve Baths* Dose-Response Relationship, Radiation Erythema Female Follow-Up Studies Humans Male Middle Aged Mineral Waters* Psoriasis / radiotherapy, therapy* Severity of Illness Index Single-Blind Method Sodium Chloride / adverse effects, therapeutic use* Treatment Outcome Ultraviolet Therapy* / adverse effects |
| Chemical | |
Reg. No./Substance:
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7647-14-5/Sodium Chloride |
| Comments/Corrections | |
Comment In:
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Br J Dermatol. 2006 Apr;154(4):802-3
[PMID:
16536846
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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