| A randomized comparison of intraoperative indocyanine green angiography and transit-time flow measurement to detect technical errors in coronary bypass grafts. | |
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MedLine Citation:
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PMID: 16935114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Early coronary bypass graft failures may be preventable if identified intraoperatively. The purpose of this investigation was to compare the diagnostic accuracy of two intraoperative graft assessment techniques, transit-time ultrasound flow measurement and indocyanine green fluorescent-dye graft angiography. METHODS: Patents undergoing isolated coronary artery bypass grafting with no contraindications for postoperative angiography were enrolled in the study. Patients were randomly assigned to be evaluated with either indocyanine green angiography (Novadaq Spy angiography system; Novadaq Technologies Inc, Concord, Ontario, Canada) and then transit-time ultrasonic flow measurement (Medtronic Medi-Stim Butterfly Flowmeter TTF measurement system; Medtronic Inc, Minneapolis, Minn) or transit-time flow then indocyanine green angiography. Patients underwent x-ray angiography on postoperative day 4. The primary end point of the trial was to determine the sensitivity and specificity of the two techniques versus reference standard x-ray angiography to detect graft occlusion or greater than 50% stenosis in the graft or perianastomotic area. RESULTS: Between February 2004 and March 2005, 106 patients were enrolled and x-ray angiography was performed in 46 patients. In total, 139 grafts were reviewed with all three techniques and 12 grafts (8.2%) were demonstrated to have greater than 50% stenosis or occlusion by the reference standard. The sensitivity and specificity of indocyanine green angiography to detect greater than 50% stenosis or occlusion was 83.3% and 100%, respectively. The sensitivity and specificity of transit-time ultrasonic flow measurement to detect greater than 50% stenosis or occlusion was 25% and 98.4%, respectively. The P value for the overall comparison of sensitivity and specificity between indocyanine green angiography and transit-time flow ultrasonography was .011. The difference between sensitivity for indocyanine green angiography and transit-time flow measurement was 58% with a 95% confidence interval of 30% to 86%, P = .023. CONCLUSION: Indocyanine green angiography provides better diagnostic accuracy for detecting clinically significant graft errors than does transit-time ultrasound flow measurement. |
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Authors:
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Nimesh D Desai; Senri Miwa; David Kodama; Taadaki Koyama; Gideon Cohen; Marc P Pelletier; Eric A Cohen; George T Christakis; Bernard S Goldman; Stephen E Fremes |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2006-07-28 |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 132 ISSN: 1097-685X ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-28 Completed Date: 2006-10-19 Revised Date: 2007-02-23 |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 585-94 Citation Subset: AIM; IM |
Affiliation:
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Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. nimesh.desai@utoronto.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Flow Velocity Coloring Agents / diagnostic use* Coronary Angiography / methods* Coronary Artery Bypass* Coronary Circulation* Female Humans Indocyanine Green / diagnostic use* Intraoperative Care* Male Postoperative Complications / prevention & control* Prospective Studies Reproducibility of Results Sensitivity and Specificity Ultrasonography, Interventional* |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 3599-32-4/Indocyanine Green |
| Comments/Corrections | |
Comment In:
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J Thorac Cardiovasc Surg. 2007 Feb;133(2):592-3
[PMID:
17258621
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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